Medicine : Zylopred Eye Drop

Name:Zylopred Eye Drop
Type:Drop
Manufacturer:Allergan India Pvt Ltd
Generic Use:Gatifloxacin , Prednisolone
Composition:Gatifloxacin(0.3%w/v) , Prednisolone(1%w/v)
Substitutes:z pred(5ml) , zylopred eye drop , gatiquin p eye drops(10ml) , z pred(5ml) , zylopred eye drop , gatiquin p eye drops(10ml)


Generic ( Gatifloxacin )



Typical use Of Gatifloxacin :Bacterial Infection
Mechanism of action of Gatifloxacin :The Bactericidal Action Of Gatifloxacin Results From Inhibition Of The Enzymes Topoisomerase II (DNA Gyrase) And Topoisomerase IV, Which Are Required For Bacterial DNA Replication, Transcription, Repair, And Recombination.
Drug Interaction of Gatifloxacin :Antacids, Ferrous Salts, Bismuth Subsalicylate, Sucralfate And Zinc Salts Reduce Bioavailability Of Gatifloxacin. May Increase Digoxin Plasma Levels. Probenecid, Cimetidine And Loop Diuretics Increase Gatifloxacin Levels. NSAIDs May Increase The Risk Of CNS Stimulation And Convulsions. Concurrent Use Of Bepridil, Cisapride, Erythromycin, Pentamidine, Phenothiazines, Or TCAs May Prolong QT Interval.
Side effects of Gatifloxacin :Dizziness, Diarrhea, Insomnia, Skin Rash, Nausea And Vomiting, Abnormal LFT, Abdominal Discomfort, QT Prolongation, Hyperglycemia In Diabetic Patients.

INTERACTIONS OF GATIFLOXACIN


How Gatifloxacin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Gatifloxacin will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Gatifloxacin

No Studies Found






Generic ( Prednisolone )



Typical use Of Prednisolone :Adrenal Insufficiency, Asthma, Blood Malignancies, Connective Tissue Diseases, Liver Diseases, Ocular Diseases, Renal Diseases, Respiratory Disease, Suppression Of Inflammatory And Allergic Disorders.
Mechanism of action of Prednisolone :Glucocorticoids Such As Prednisolone Can Inhibit Leukocyte Infiltration At The Site Of Inflammation, Interfere With Mediators Of Inflammatory Response, And Suppress Humoral Immune Responses. The Antiinflammatory Actions Of Glucocorticoids Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes. Prednisolone Reduces Inflammatory Reaction By Limiting The Capillary Dilatation And Permeability Of The Vascular Structures. These Compounds Restrict The Accumulation Of Polymorphonuclear Leukocytes And Macrophages And Reduce The Release Of Vasoactive Kinins.
Drug Interaction of Prednisolone :Rifampin Decreases Blood Levels Of Prednisolone By Increasing Its Breakdown In The Liver. The Dose Of Prednisolone May Need To Be Increased In Order To Avoid Therapeutic Failure. Corticosteroids Have Variable Effects Of Warfarin (Coumadin) Therapy. Coagulation Levels Should Be Monitored More Closely When Anticoagulants Are Combined With Corticosteroids. Estrogens May Increase The Levels Of Prednisolone By Decreasing Its Breakdown. When Estrogens Are Used With Prednisolone, Side Effects Of Prednisolone Should Be Monitored.
Side effects of Prednisolone :On Long Term Use Cushing's Syndrome And Growth Retardation In Childn; Osteoporosis, Fractures. Peptic Ulceration; Glaucoma, Cataract May Occur.

INTERACTIONS OF PREDNISOLONE


How Prednisolone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Prednisolone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Prednisolone

No Studies Found