Medicine : Zole F Oint(5gm)

Name:Zole F Oint(5gm)
Manufacturer:Ranbaxy Laboratories Ltd
Generic Use:Miconazole Nitrate , Fluocinolone
Composition:Miconazole Nitrate(2 % W/v) , Fluocinolone(0.01 % W/v)

Generic ( Miconazole Nitrate )

Typical use Of Miconazole Nitrate :Balanitis, Candidosis, Fungal Infection, Vulvo-vaginal Candidosis.
Mechanism of action of Miconazole Nitrate :Miconazole Interacts With 14-? Demethylase, A Cytochrome P-450 Enzyme Necessary To Convert Lanosterol To Ergosterol, Causes Inhibition Of Ergosterol Synthesis Results In Increased Cellular Permeability Causing Leakage Of Cellular Contents. Miconazole May Also Inhibit Endogenous Respiration, Interact With Membrane Phospholipids, Inhibit The Transformation Of Yeasts To Mycelial Forms, Inhibit Purine Uptake, And Impair Triglyceride And/or Phospholipid Biosynthesis.
Drug Interaction of Miconazole Nitrate :Miconazole (Nitrate) Is Known To Interact With Other Drugs Like Alprazolam, Amphotericin B,astemizole, Carbamazepine, Cisapride, Fosphenytoin, Phenytoin (Na). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Miconazole Nitrate :Cardiac Arrhythmias, Phlebitis, Pruritis, Arachnoiditis, Cardiac Arrest, Anaphylaxis, Drowsiness, Anorexia, Rashes, GI Upset, Flushing, Nausea And Vomiting


How Miconazole Nitrate will impact on Pregnancy ?

Information Not Available.

How Miconazole Nitrate will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Miconazole Nitrate

Information Not Available.

Generic ( Fluocinolone )

Typical use Of Fluocinolone :Asthma Attacks
Mechanism of action of Fluocinolone :Fluocinonide Binds To The Cytosolic Glucocorticoid Receptor. After Binding The Receptor The Newly Formed Receptor-ligand Complex Translocates Itself Into The Cell Nucleus, Where It Binds To Many Glucocorticoid Response Elements (GRE) In The Promoter Region Of The Target Genes. The DNA Bound Receptor Then Interacts With Basic Transcription Factors, Causing The Increase In Expression Of Specific Target Genes. The Anti-inflammatory Actions Of Corticosteroids Are Thought To Involve Lipocortins, Phospholipase A2 Inhibitory Proteins Which, Through Inhibition Arachidonic Acid, Control The Biosynthesis Of Prostaglandins And Leukotrienes. Specifically Glucocorticoids Induce Lipocortin-1 (annexin-1) Synthesis, Which Then Binds To Cell Membranes Preventing The Phospholipase A2 From Coming Into Contact With Its Substrate Arachidonic Acid. This Leads To Diminished Eicosanoid Production.
Drug Interaction of Fluocinolone :Tell Your Doctor Or Pharmacist Of All Prescription And Nonprescription/herbal Products You May Use, Especially Of Oral Corticosteroids (e.g., Prednisone), Drugs That Suppress The Immune System (e.g., Cyclosporine).
Side effects of Fluocinolone :Telangiectasia, Striae, Glaucoma, Cataract, Growth Retardation, Adrenal Suppression, Epidermal Thinning, Raised Intracranial Pressure, Allergic Reactions, Perioral Dermatitis, Rebound Pustulation.


How Fluocinolone will impact on Pregnancy ?

Information Not Available.

How Fluocinolone will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Fluocinolone

Information Not Available.