Medicine : Wokadinem (10gm)

Name:Wokadinem (10gm)
Type:Cream
Manufacturer:Wockhardt Ltd
Generic Use:Metronidazole , Povidone Iodine
Composition:Metronidazole(0.01) , Povidone Iodine(0.05)
Substitutes:wokadinem (10gm) , wokadinem (10gm)


Generic ( Metronidazole )



Typical use Of Metronidazole :Amoebiasis, Giardiasis, Trichomonas Vaginitis, Anaerobic Infections, Ulcerative Gingivitis.Eradication Of H.pylori Associated With Peptic Ulcer Disease.Antibiotic-associated Coulitis. Trichomoniasis, Balantidiasis, Blastocyatis Hominis Infection. Adjunct To Treatment Of Chronic Periodontal Infections. Rosacea.
Mechanism of action of Metronidazole :Metronidazole Is Converted To Reduction Products That Interact With DNA To Cause Destruction Of Helical DNA Structure And Strand Leading To A Protein Synthesis Inhibition And Cell Death In Susceptible Organisms. It Is Effective Against A Wide Range Of Organisms Including E. Histolytica, T. Vaginalis, Giardia, Anaerobes E.g. Bacterioides Sp, Fusobacterium Sp, Clostridium Sp.
Drug Interaction of Metronidazole :Acute Psychoses Or Confusion With Disulfiram. It Has Synergistic Effect With Other Antimicrobials. Effects Reduced With Phenobarbital Or Phenytoin. Disulfiram-like Reaction With Alcohol. Increased Risk Of Adverse Effects Of Coumarin Anticoagulants, Phenytoin, Lithium, Ciclosporin, Fluorouracil. Increased Risk Of Neurological Effects With Cimetidine.
Side effects of Metronidazole :GI Disturbances E.g. Nausea, Unpleasant Metallic Taste, Vomiting, Diarrhoea Or Constipation. Furred Tongue, Glossitis, And Stomatitis Due To Overgrowth Of Candida. Rarely, Antibiotic-associated Colitis. Weakness, Dizziness, Ataxia, Headache, Drowsiness, Insomnia, Changes In Mood Or Mental State. Numbness Or Tingling In The Extremities, Epileptiform Seizures (high Doses Or Prolonged Treatment). Transient Leucopenia And Thrombocytopenia. Hypersensitivity Reactions. Anaphylaxis.

INTERACTIONS OF METRONIDAZOLE


How Metronidazole will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Metronidazole will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Metronidazole

No Studies Found






Generic ( Povidone Iodine )



Typical use Of Povidone Iodine :Vaginal Candidiasis.Treatment And Prevention Of Wound Infection.Oral Hygiene.Oral Candidiasis.
Mechanism of action of Povidone Iodine :Povidone-iodine Is An Iodophore With A Powerful Broad-spectrum Germicidal Activity Against A Wide Range Of Bacteria, Viruses, Fungi, Protozoa And Spores. Povidone-iodine Acts By Iodinating And Oxidizing Microbial Protoplasm.
Drug Interaction of Povidone Iodine :Povidone-Iodine Is Known To Interact With Other Drugs Like Chlorhexidine, Silver Sulphadiazine. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Povidone Iodine :Hypersensitivity Reactions, Renal Impairment, Hyperthyroidism, Hypernatremia, Metabolic Acidosis, Rashes, Pruritus, Skin Irritation, Local Edema, Mucous Membrane Irritation.

INTERACTIONS OF POVIDONE IODINE


How Povidone Iodine will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Povidone Iodine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Povidone Iodine

No Studies Found