Medicine : Unitrexate (50mg)

Name:Unitrexate (50mg)
Manufacturer:United Biotech Pvt Ltd
Generic Use:Methotrexate
Substitutes:mexate (100mg) , unitrexate (50mg) , remtrex (50mg) , caditrex (50mg)

Generic ( Methotrexate )

Typical use Of Methotrexate :Adjunct In The Short Term Symtomastic Treatment Of Muscle Spasm.
Mechanism of action of Methotrexate :Methotrexate Is A Folic Acid Antagonist That Inhibits DNA Synthesis. It Irreversibly Binds To Dihydrofolate Reductase, Inhibiting The Formation Of Reduced Folates, And Thymidylate Synthetase, Resulting In Inhibition Of Purine And Thymidylic Acid Synthesis.
Drug Interaction of Methotrexate :Decreased Effectiveness With Folic Acid And Its Derivatives. Potentially Fatal: Increased Toxicity With NSAIDs And Salicylates; Probenecid; Some Penicillins; Aminoglycosides Neomycin And Paromomycin; Sulfonamides Such As Sulfafurazole And Sulfamethoxazole; Co-trimoxazole Or Trimethoprim; Nephrotoxic Agents (e.g. Cisplatin); Ciclosporin; Etretinate. Synergistic Enhancement Of Effects With Fluorouracil. Increased Bioavailability Of Mercaptopurine. Reduces Serum-valproate Concentrations. Reduced Serum Concentrations With Colestyramine. Increased Serum Concentrations With Omeprazole.
Side effects of Methotrexate :Ulceration Of The Mouth And GI Disturbances, Bone Marrow Depression, Hepatotoxicity, Renal Failure, Skin Reactions, Alopecia, Megaloblastic Anaemia, Osteoporosis, Precipitation Of Diabetes, Arthralgias, Necrosis Of Soft Tissue And Bone, Anaphylaxis, Impaired Fertility. Potentially Fatal: Pulmonary Reactions (e.g. Interstitial Lung Disease); Neurotoxicity (e.g. Leukoencephalopathy, Paresis, Demyelination) With Intrathecal Use.


How Methotrexate will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Methotrexate will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Methotrexate

No Studies Found