Medicine : Triomune (30tab)

Name:Triomune (30tab)
Type:Tablet
Manufacturer:Cipla Ltd
Generic Use:Lamivudine , Stavudine
Composition:Lamivudine(150mg) , Stavudine(200mg)
Substitutes:triomune (30tab) , triomune (30tab)


Generic ( Lamivudine )



Typical use Of Lamivudine :Portal Systemic Encephalopathy, Chronic Or Habitual Constipation.
Mechanism of action of Lamivudine :Lamivudine Is A Synthetic Nucleoside Analogue And Is Phosphorylated Intracellularly To Its Active 5'-triphosphate Metabolite, Lamivudine Triphosphate (L-TP). This Nucleoside Analogue Is Incorporated Into Viral DNA By HIV Reverse Transcriptase And HBV Polymerase, Resulting In DNA Chain Termination.
Drug Interaction of Lamivudine :Trimethoprim/sulfamethoxazole (Bactrim) Increases The Concentration Of Lamivudine In The Body.
Side effects of Lamivudine :The Symptomatic Adverse Reactions Produced By Lamivudine Are More Or Less Tolerable And If They Become Severe, They Can Be Treated Symptomatically, These Include Headache, Fatigue, Diarrhea, Abdominal Pain, Malaise, Nausea And Vomiting, Respiratory Tract Infections, Abdominal Discomfort.

INTERACTIONS OF LAMIVUDINE


How Lamivudine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Lamivudine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Lamivudine

No Studies Found






Generic ( Stavudine )



Typical use Of Stavudine :HIV Infection.
Mechanism of action of Stavudine :Stavudine Inhibits The Activity Of HIV-1 Reverse Transcriptase (RT) Both By Competing With The Natural Substrate DGTP And By Its Incorporation Into Viral DNA.
Drug Interaction of Stavudine :Zidovudine Prevents The Conversion Of Stavudine To Its Active Form (stavudine Triphosphate) And This Reduces The Action Of Stavudine Against The HIV Virus. Therefore Stavudine Should Not Be Combined With Zidovudine.
Side effects of Stavudine :Flatulence, Dizziness, Headache, Drowsiness, Fatigue, Anorexia, Diarrhea, Fever, Myalgia, Anxiety, Dyspnea, Rashes, Urticaria, Depression, Cough, Arthralgia, Nausea And Vomiting, GI Disturbance, Abnormal Dreams.

INTERACTIONS OF STAVUDINE


How Stavudine will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Stavudine will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Stavudine

No Studies Found