Medicine : Toff Dc Supp(100ml)

Name:Toff Dc Supp(100ml)
Type:Syrup
Manufacturer:Panacea Biotec Ltd
Generic Use:Dextromethorphan Hydrobromide , Chlorpheniramine Maleate , Phenylephrine Hydrochloride
Composition:Dextromethorphan Hydrobromide(10 Mg/5ml) , Chlorpheniramine Maleate(2 Mg/5ml) , Phenylephrine Hydrochloride(5 Mg/5ml)
Substitutes:torex cough syp juniour(60ml) , toff dc supp(100ml) , torex cough syp juniour(60ml) , toff dc supp(100ml) , torex cough syp juniour(60ml) , toff dc supp(100ml)


Generic ( Dextromethorphan Hydrobromide )



Typical use Of Dextromethorphan Hydrobromide :Cough Suppressant
Mechanism of action of Dextromethorphan Hydrobromide :Dextromethorphan Is An Opioid-like Drug That Binds To And Acts As Antagonist To The NMDA Glutamatergic Receptor, It Is An Agonist To The Opioid Sigma 1 And Sigma 2 Receptors, It Is Also An Alpha3/beta4 Nicotinic Receptor Antagonist And Targets The Serotonin Reuptake Pump. Dextromethorphan Is Rapidly Absorbed From The Gastrointestinal Tract, Where It Enters The Bloodstream And Crosses The Blood-brain Barrier. The First-pass Through The Hepatic Portal Vein Results In Some Of The Drug Being Metabolized Into An Active Metabolite Of Dextromethorphan, Dextrorphan, The 3-hydroxy Derivative Of Dextromethorphan.
Drug Interaction of Dextromethorphan Hydrobromide :None Mentioned.
Side effects of Dextromethorphan Hydrobromide :Dizziness, GI Disturbances.

INTERACTIONS OF DEXTROMETHORPHAN HYDROBROMIDE


How Dextromethorphan Hydrobromide will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Dextromethorphan Hydrobromide will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Dextromethorphan Hydrobromide

No Studies Found






Generic ( Chlorpheniramine Maleate )



Typical use Of Chlorpheniramine Maleate :For The Treatment Of Rhinitis, Urticaria, Allergy, Common Cold, Asthma And Hay Fever.
Mechanism of action of Chlorpheniramine Maleate :Chlorphenamine Is An H1-receptor Antagonist Which Competetively Blocks H1-receptor Sites On Tissues.
Drug Interaction of Chlorpheniramine Maleate :Avoid Excessive Alcohol Consumption. Anticholinergic Effects Of Chlorphenamine (e.g. Dry Mouth, Blurred Vision) May Be Enhanced By Drugs With Anticholinergic Effects Such As Antipsychotics, MAOI Or Tricyclic Antidepressants. Chlorphenamine Inhibits Phenytoin Metabolism And Can Lead To Phenytoin Toxicity.
Side effects of Chlorpheniramine Maleate :Blurred Vision, Dry Eyes, Mydriasis, Drowsiness, Fatigue, Headache, Dizziness, Psychomotor Impairment, Dry Mouth, Gastrointestinal Disturbances.

INTERACTIONS OF CHLORPHENIRAMINE MALEATE


How Chlorpheniramine Maleate will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chlorpheniramine Maleate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Chlorpheniramine Maleate

No Studies Found






Generic ( Phenylephrine Hydrochloride )



Typical use Of Phenylephrine Hydrochloride :Acid-related Dyspepsia, Congestion, Hypotension.
Mechanism of action of Phenylephrine Hydrochloride :Phenylephrine Is A Sympathomimetic With Mainly Direct Effects On Alpha-adrenergic Receptors And Weak Beta-adrenergic Activity. It Causes Vasoconstriction Of The Arterioles Of The Nasal Mucosa And Conjunctiva; Activates The Dilator Muscle Of The Pupil To Cause Contraction; Produces Vasoconstriction Of Arterioles In The Body And Produces Systemic Arterial Vasoconstriction.
Drug Interaction of Phenylephrine Hydrochloride :May Increase Hypertensive Effect Of Beta-blockers (nonselective).
Side effects of Phenylephrine Hydrochloride :Anxiety, Reflex Bradycardia, Tachycardia, Arrhythmias, Headache, Cold Extremities.

INTERACTIONS OF PHENYLEPHRINE HYDROCHLORIDE


How Phenylephrine Hydrochloride will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Phenylephrine Hydrochloride will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Phenylephrine Hydrochloride

No Studies Found