Medicine : Tobradex

Name:Tobradex
Type:Drop
Manufacturer:Micro Labs Ltd (gratia)
Generic Use:Dexamethasone , Tobramycin
Composition:Dexamethasone(0.001W/V) , Tobramycin(0.003W/V)
Substitutes:tobadex , ocutobd , tobradex , tobadex , ocutobd , tobradex


Generic ( Dexamethasone )



Typical use Of Dexamethasone :Anorexia In Palliative Care, Congenital Adrenal Hyperplasia, Dyspnoea, Dyspnoea In Palliative Care, Headache Due To Raised Intracranial Pressure In Palliative Care, Nausea And Vomiting (chemotherapy Induced), Pain Due To Nerve Compression In Palliative Care, Raised Intracranial Pressure, Respiratory Distress Syndrome, Shock, Suppression Of Inflammatory And Allergic Disorders.
Mechanism of action of Dexamethasone :Dexamethasone Is A Glucocorticoid Agonist. Unbound Dexamethasone Crosses Cell Membranes And Binds With High Affinity To Specific Cytoplasmic Glucocorticoid Receptors. This Complex Binds To DNA Elements (glucocorticoid Response Elements) Which Results In A Modification Of Transcription And, Hence, Protein Synthesis In Order To Achieve Inhibition Of Leukocyte Infiltration At The Site Of Inflammation, Interference In The Function Of Mediators Of Inflammatory Response, Suppression Of Humoral Immune Responses, And Reduction In Edema Or Scar Tissue. The Antiinflammatory Actions Of Dexamethasone Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes.
Drug Interaction of Dexamethasone :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Dexamethasone :Glaucoma, Peptic Ulceration, Myopathy, Osteoporosis, Growth Retardation, Aseptic Bone Necrosis, Ocular Hypertension, Subcapsular Cataract, Pancreatic Disturbance, Cushing Like Features, Oedema, Retinal Detachment, Nausea, Vomiting, Insomnia, Nervousness, Nocturia, Increased Appetite, Obesity, Facial Rounding, Fragility Of Skin, Euphoria, Glucose Intolerance.

INTERACTIONS OF DEXAMETHASONE


How Dexamethasone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Dexamethasone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Dexamethasone

No Studies Found






Generic ( Tobramycin )



Typical use Of Tobramycin :Bacterial Infections, Biliary Tract Infections, Chronic Pulmonary Pseudomonas Aeruginosa Infection In Cystic Fibrosis Patients, Cystic Fibrosis, Endocarditis, Eye Infections, Gram +ve (some) And Gram -ve (many) Infections, Heart Failure, Iron Deficiency Anaemia, NSAID-associated Ulceration, Oliguria Due To Renal Failure, Pneumonia In Hospital Patients, Prophylaxis Of Stress Ulceration, Respiratory Tract Infections.
Mechanism of action of Tobramycin :Tobramycin Binds Irreversibly To One Of Two Aminoglycoside Binding Sites On The 30 S Ribosomal Subunit, Inhibiting Bacterial Protein Synthesis. Tobramycin May Also Destabilize Bacterial Memebrane By Binding To 16 S 16 S R-RNA.
Drug Interaction of Tobramycin :Tobramycin Is Known To Interact With Other Drugs Like Atracurium (Besylate), Calcium Gluconate, Carbenicillin (Na), Cefaclor (Monohydrate), Cefotaxime, Cephaloridine, Cisplatin, Ethacrynic Acid, Frusemide Or Furosemide, Gentamicin, Piperacillin (Na), Polymyxin B (Sulphate), Tubocurarine (Cl), Vancomycin (HCl), Vecuronium (Br). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Tobramycin :Ototoxicity, Elevation In Serum Creatinine, Neuromuscular Blockage, Skin Reactions, Maculopapular Rash, Urticaria, Local Pain, Phlebitis.

INTERACTIONS OF TOBRAMYCIN


How Tobramycin will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Tobramycin will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Tobramycin

No Studies Found