Medicine : Tidomet E(150tab)

Name:Tidomet E(150tab)
Type:Tablet
Manufacturer:Torrent Pharmaceuticals Ltd
Generic Use:Levodopa , Carbidopa , Entacapone
Composition:Levodopa(150 Mg) , Carbidopa(37.5 Mg) , Entacapone(200 Mg)
Substitutes:tidomet e(150tab) , tidomet e(150tab) , tidomet e(150tab)


Generic ( Levodopa )



Typical use Of Levodopa :Idiopathic, Post-encephalitis And Arteriosclerotic Parkinsonism.
Mechanism of action of Levodopa :Striatal Dopaminergic Neurotransmission May Be Enhanced By Exogenous Supplementation Of Dopamine Through Administration Of Dopamine's Precursor, Levodopa. A Small Percentage Of Each Levodopa Dose Crosses The Blood-brain Barrier And Is Decarboxylated To Dopamine. This Newly Formed Dopamine Then Is Available To Stimulate Dopaminergic Receptors, Thus Compensating For The Depleted Supply Of Endogenous Dopamine.
Drug Interaction of Levodopa :Levodopa Is Known To Interact With Other Drugs Like Adrenaline, Alprazolam, Amitriptyline (HCl), Benserazide (HCl), Biperiden (HCl), Bupropion (HCl), Cabergoline, Clonidine (HCl), Dacarbazine, Diazepam, Diazoxide, Droperidol, Drotaverine, Ephedrine, Flupenthixol (HCl And Decanoate), Furazolidone, Gonadorelin (HCl), Guanethidine, Haloperidol, Halothane, Imipramine (HCl), Iron Salts, Isocarboxazid, Isoproterenol, Lisuride, Methyldopa, Metoclopramide (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Levodopa :Hallucinations, Delirium, Dyskinesias, Mental Disturbances, Cardiac Irregularities, Bradyphrenia, Nausea, Vomiting, Anorexia, Diarrhea, Palpitation, Constipation, Abdominal Pain, GI Upset, Elevated Alkaline Phosphatase.

INTERACTIONS OF LEVODOPA


How Levodopa will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Levodopa will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Levodopa

No Studies Found






Generic ( Carbidopa )



Typical use Of Carbidopa :In Combination With Levodopa Used In The Management Of Parkinsons Disease. Levodopa Combination Is Also Used For The Treatment Of Restless Leg Syndrome.
Mechanism of action of Carbidopa :Carbidopa When Mixed With Levodopa, Carbidopa Inhibits The Peripheral Conversion Of Levodopa To Dopamine And The Decarboxylation Of Oxitriptan To Serotonin By Aromatic L-amino Acid Decarboxylase. This Results In Increased Amount Of Levodopa And Oxitriptan Available For Transport To The CNS. Carbidopa Also Inhibits The Metabolism Of Levodopa In The GI Tract, Thus, Increasing The Bioavailability Of Levodopa.
Drug Interaction of Carbidopa :Carbidopa Is Known To Interact With Other Drugs Like Spiramycin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Carbidopa :Postural Hypotension, Psychiatric Disturbances, Fluctuating Disability, Dyskinesias, Nausea, Vomiting, Palpitation, GI Upset.

INTERACTIONS OF CARBIDOPA


How Carbidopa will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Carbidopa will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Carbidopa

No Studies Found






Generic ( Entacapone )



Typical use Of Entacapone :In Adjunctive Therapy As An Alternative Drug Of Choice In Parkinson's Disease.
Mechanism of action of Entacapone :Entacapone Is A Selective And Reversible Inhibitor Of Catechol- O- Methyltransferase (COMT). The Mechanism Of Action Of Entacapone Is Believed To Be Through Its Ability To Inhibit COMT And Alter The Plasma Pharmacokinetics Of Levodopa. When Entacapone Is Given In Conjunction With Levodopa And An Aromatic Amino Acid Decarboxylase Inhibitor, Such As Carbidopa, Plasma Levels Of Levodopa Are Greater And More Sustained Than After Administration Of Levodopa And An Aromatic Amino Acid Decarboxylase Inhibitor Alone.
Drug Interaction of Entacapone :Not Known
Side effects of Entacapone :Dizziness, Diarrhea, Constipation, Abdominal Pain, Dry Mouth, Nausea And Vomiting, Dyskinesia, Rarely Hepatitis, Colored (reddish-brown) Urine.

INTERACTIONS OF ENTACAPONE


How Entacapone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Entacapone will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Entacapone

No Studies Found