Medicine : Sumth Crm

Name:Sumth Crm
Type:Cream
Manufacturer:Aristo Pharmaceuticals Pvt Ltd
Generic Use:Calcium , Hydrocortisone , Lignocaine
Composition:Calcium(0.25%W/V) , Hydrocortisone(0.25%W/V) , Lignocaine(3%W/V)
Substitutes:sumth crm , sumth crm , sumth crm


Generic ( Calcium )


Typical use Of Calcium :Calcium Supplements Are Usually Used To Prevent Or Treat Low Blood Calcium Levels In People Who Do Not Get Enough Calcium From Their Food. The Amount Of Calcium Required Everyday Varies With Age And Gender. The Demand Is Generally Higher During Childhood, Pregnancy, Lactation And Postmenopausal Phase. Calcium Supplements Are Used To Treat Patients With Calcium Deficiency, Brittle Bones, Reduced Absorption Of Nutrients After Surgery Performedto Remove All Or Part Of The Stomach, Bone Softening And Bone Disease Due To Vitamin D Deficiency.
Mechanism of action of Calcium :Calcium Is Necessary For Normal Functioning Of Nerves, Cells, Muscle, And Bone. If There Is Not Enough Calcium In The Blood, Then The Body Will Take Calcium From Bones, Thereby Weakening Bones. On Administration Of Calcium Supplements, About One-third Of The Ingested Calcium Is Absorbed From The Small Intestine. Absorption Decreases With Age And May Be More Efficient When The Body Is Deficient In Calcium Or From Diets Deficient In Calcium. The Best-absorbed Form Of Calcium From A Pill Is A Calcium Salt Like Carbonate Or Phosphate. Calcium Gluconate And Calcium Lactate Are Absorbed Well By Pregnant Women. Elderly Population Absorb Calcium Lactate, Gluconate And Citrate Better Unless They Take Their Calcium Supplement With A Full Breakfast.
Drug Interaction of Calcium :Care Should Be Taken While Administering Calcium In Patients Receiving Vitamin Or Mineral Preparations As They Contain Additional Calcium. Calcium Increases The Effects Of Digoxin On The Heart. It Is Known To Reduce The Absorption Of Tetracycline Drugs. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Calcium :Constipation

INTERACTIONS OF CALCIUM

How Calcium will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Calcium will impact during lactation(breastfeeding) ?

Safest: Evidence From Clinical Studies Has Shown That This Drug When Taken By Breastfeeding Mothers Has Not Shown Any Major Side Effects In Infants. The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare Or The Drug Does Not Reach The Infant Through Breast Milk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Calcium

No Studies Found





Generic ( Hydrocortisone )


Typical use Of Hydrocortisone :Replacement Therapy: Adrenal Insufficiency. Adrenogenital Syndrome.Nonendocrine Diseases: Rheumatoid Arthirits. Osteoarthritis, Acute Gouty Arthirits.Collagen Diseases E.g. Systemic Lupus Erythematosus, Polyarteritis Nodosa, Dermatomyositis, Nephritic Syndrome, Glomerulonephritis And Related Diseases.Severe Allergic Reactions E.g. Anaphylaxis, Angioneurotic Edema, Urticaria And Serum Sickness And Related Diseases.Autoimmune Diseases E.g. Haemolytic Anaemia, Idiopathic Thrombocytopenic Purpura, Active Chronic Hepatitis And Related Diseases.Other Lung Diseases E.g. Pulmonary Edema, Accelerate Lung Maturation And Surfactant Production In The Foetus And Prevent Respiratory Distress Syndrome At Birth.Infective Diseases E.g. Severe Forms Of Tuberculosis, Severe Lepra Reaction, Certain Forms Of Bacterial Meningitis And Pneumocystis Carinii Pneumonia With Hypoxia In AIDS Patients Along With Proper Antibiotic Cover.Eye Diseases E.g. Inflammatory Ocular Diseases, Allergic Conjunctivitis, Iritis, Iridocyclitis, Keratitis, Retinitis, Optic Neuritis, Uveitis.Skin Diseases E.g. Eczematous Skin Diseases. Pemphigus Vulgaris, Exfoliative Dermatitis, Stevens Johnson Syndrome.Intestinal Diseases E.g. Ulcerative Colitis, Crohns Disease, Coeliac Disease Are Chronic Inflammatory Intestinal Diseases.Cerebral Edema.Malignancies E.g. Acute Lymphatic Leukaemia, Hodgkins And Other Lymphomas. Hormone Responsive Breast Carcinoma.Organ Transplantation And Skin Allograft.Septic Shock.Thyroid Storm.
Mechanism of action of Hydrocortisone :Hydrocortisone Binds To The Cytosolic Glucocorticoid Receptor. After Binding The Receptor The Newly Formed Receptor-ligand Complex Translocates Itself Into The Cell Nucleus, Where It Binds To Many Glucocorticoid Response Elements (GRE) In The Promoter Region Of The Target Genes. The DNA Bound Receptor Then Interacts With Basic Transcription Factors, Causing The Increase In Expression Of Specific Target Genes. The Anti-inflammatory Actions Of Corticosteroids Are Thought To Involve Lipocortins, Phospholipase A2 Inhibitory Proteins Which, Through Inhibition Arachidonic Acid, Control The Biosynthesis Of Prostaglandins And Leukotrienes. Specifically Glucocorticoids Induce Lipocortin-1 (annexin-1) Synthesis, Which Then Binds To Cell Membranes Preventing The Phospholipase A2 From Coming Into Contact With Its Substrate Arachidonic Acid. This Leads To Diminished Eicosanoid Production.
Drug Interaction of Hydrocortisone :Hydrocortisone Is Known To Interact With Other Drugs Like Aminoglutethimide, Amobarbital, Amphotericin B, Ascorbic Acid, Aspirin, Carbamazepine, Frusemide Or Furosemide, Gentamicin, Ipilimumab, Lofexidine, Metyrosine, Natamycin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Hydrocortisone :Convulsions, GI Bleeding, Telangiectasia, Striae, Glaucoma, Cataract, Pancreatitis, Hypersensitivity Reactions, Osteoporosis, Psychosis, Increased Intracranial Pressure, Growth Retardation, Glucose Intolerance, Epidermal Thinning, Vertebral Fractures, Avascular Necrosis, Papilloedema, Opthalmic Fungal Or Viral Disease, Dendritic Corneal Ulcers, Thromboembolic Disorder, Long Bone Fractures, Hypokalemic Alkalosis, Anaphylactoid Reactions, Addisonian Crises, CHF, Opportunistic Infections, Acute Pancreatitis, Insomnia, Irritation, Allergic Reactions, Itching, Burning, Depression, Weight Gain, Acne, Euphoria, Menstrual Irregularity, Perioral Dermatitis.

INTERACTIONS OF HYDROCORTISONE

How Hydrocortisone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Hydrocortisone will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Hydrocortisone

No Studies Found





Generic ( Lignocaine )


Typical use Of Lignocaine :Information Not Available.
Mechanism of action of Lignocaine :Information Not Available.
Drug Interaction of Lignocaine :Information Not Available.
Side effects of Lignocaine :Information Not Available.

INTERACTIONS OF LIGNOCAINE

How Lignocaine will impact on Pregnancy ?

Information Not Available.

How Lignocaine will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Lignocaine

Information Not Available.