Medicine : Sternon G Gel(20gm)

Name:Sternon G Gel(20gm)
Type:Gel
Manufacturer:Palsons Derma
Generic Use:Betamethasone , Gentamicin
Composition:Betamethasone(0.05 % W/v) , Gentamicin(0.1% W/v)
Substitutes:sternon g gel(20gm) , sternon g gel(20gm)


Generic ( Betamethasone )



Typical use Of Betamethasone :Replacement Therapy: Adrenal Insufficiency. Adrenogenital Syndrome.Nonendocrine Diseases: Rheumatoid Arthirits. Osteoarthritis, Acute Gouty Arthirits. Collagen Diseases E.g. Systemic Lupus Erythematosus, Polyarteritis Nodosa, Dermatomyositis, Nephritic Syndrome, Glomerulonephritis And Related Diseases.Severe Allergic Reactions E.g. Anaphylaxis, Angioneurotic Edema, Urticaria And Serum Sickness And Related Diseases.Autoimmune Diseases E.g. Haemolytic Anaemia, Idiopathic Thrombocytopenic Purpura, Active Chronic Hepatitis And Related Diseases.Other Lung Diseases E.g. Pulmonary Edema, Accelerate Lung Maturation And Surfactant Production In The Foetus And Prevent Respiratory Distress Syndrome At Birth.Infective Diseases E.g. Severe Forms Of Tuberculosis, Severe Lepra Reaction, Certain Forms Of Bacterial Meningitis And Pneumocystis Carinii Pneumonia With Hypoxia In AIDS Patients Along With Proper Antibiotic Cover.Eye Diseases E.g. Inflammatory Ocular Diseases, Allergic Conjunctivitis, Iritis, Iridocyclitis, Keratitis, Retinitis, Optic Neuritis, Uveitis.Skin Diseases E.g. Eczematous Skin Diseases. Pemphigus Vulgaris, Exfoliative Dermatitis, Stevens Johnson Syndrome.Intestinal Diseases E.g. Ulcerative Colitis, Crohns Disease, Coeliac Disease Are Chronic Inflammatory Intestinal Diseases.Cerebral Edema.Malignancies E.g. Acute Lymphatic Leukaemia, Hodgkins And Other Lymphomas. Hormone Responsive Breast Carcinoma.Organ Transplantation And Skin Allograft.Septic Shock.Thyroid Storm.
Mechanism of action of Betamethasone :Betamethasone Is A Glucocorticoid Receptor Agonist. This Leads To Changes In Genetic Expression Once This Complex Binds To The GRE. The Antiinflammatory Actions Of Corticosteroids Are Thought To Involve Lipocortins, Phospholipase A2 Inhibitory Proteins Which, Through Inhibits Arachidonic Acid, Control The Biosynthesis Of Prostaglandins And Leukotrienes.
Drug Interaction of Betamethasone :Betamethasone Is Known To Interact With Other Drugs Like Amphotericin B, Carbamazepine, Lofexidine, Metyrosine, Oxandrolone, Perindopril, Phenytoin (Na), Rifampicin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Betamethasone :Atrophy, Steroid Purpura, Steroid Purpura, Skin Fragility, Angioedema, Perioral Dermatitis, Vertigo, Headache, Diarrhea, Fever, Anxiety, Constipation, Abdominal Pain, Sweating, Erythema, Hypotension, Arthralgia, Acne, Hypersensitivity Reactions, Menstrual Irregularity, Cataract, Hypertrichosis, Pigmentation, Superficial Blood Vessels Dilatation, Local Hypopigmentation.

INTERACTIONS OF BETAMETHASONE


How Betamethasone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Betamethasone will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Betamethasone

No Studies Found






Generic ( Gentamicin )



Typical use Of Gentamicin :Severe Infections Caused By Susceptible Gm Negative Organisms Eg - Billary Tract Infections, Brucellosis, Cat Scratch Disease, Cystic Fibrosis, Endocarditis, Endometritis, Gastroenteritis, Granuloma Inguinale, Listeriosis, Meningitis, Otitis Externa, Pelvic Inflammatory Disease, Peritonitis, Plaque, Pneumonia, Septicaemia, Skin Infections, UTI.
Mechanism of action of Gentamicin :Aminoglycosides Like Gentamicin "irreversibly" Bind To Specific 30S-subunit Proteins And 16S RRNA. Specifically Gentamicin Binds To Four Nucleotides Of 16S RRNA And A Single Amino Acid Of Protein S12. This Interferes With Decoding Site In The Vicinity Of Nucleotide 1400 In 16S RRNA Of 30S Subunit. This Region Interacts With The Wobble Base In The Anticodon Of TRNA. This Leads To Interference With The Initiation Complex, Misreading Of MRNA So Incorrect Amino Acids Are Inserted Into The Polypeptide Leading To Nonfunctional Or Toxic Peptides And The Breakup Of Polysomes Into Nonfunctional Monosomes.
Drug Interaction of Gentamicin :Gentamicin Is Known To Interact With Other Drugs Like Atracurium (Besylate), Capreomycin, Cefaclor (Monohydrate), Cefotaxime, Cisplatin, Clindamycin, Cyclosporin A, Cytarabine (HCl), Ethacrynic Acid, Ethacrynic Acid, Floxacillin (Na), Foscarnet (Na), Frusemide Or Furosemide, Hydrocortisone, Indomethacin.
Side effects of Gentamicin :Encephalopathy, Convulsions, Hallucinations, Nephrotoxicity, Neuromuscular Blockage, Nephrotoxicity, Ototoxicity, Dizziness, Vertigo, Fever, Ototoxicity, Skin Rashes, Exfoliative Dermatitis, Eosinophilia, Purpura, Angioedema, Pyuria, Proteinuria, Azotemia.

INTERACTIONS OF GENTAMICIN


How Gentamicin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Gentamicin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Gentamicin

No Studies Found