Medicine : Spiromide

Manufacturer:Rpg Life Sciences Ltd (acumed)
Generic Use:Furosemide , Spironolactone
Composition:Furosemide(20mg) , Spironolactone(50mg)
Substitutes:aldostix , fruselac tab. , amifru s , lasilactone (50mg) , spiromide , aldostix , fruselac tab. , amifru s , lasilactone (50mg) , spiromide

Generic ( Furosemide )

Typical use Of Furosemide :Asthma, Congestive Heart Failure, Degradation Of Pancreatic Enzyme Suppliments, Edema, Heart Failure, Hypertension, Long-term Treatment Of Healed Reflux Oesophagitis, Oedema, Oliguria, Oliguria Due To Renal Failure, Oliguria Due To Renal Failure, Pulmonary Edema
Mechanism of action of Furosemide :Furosemide Inhibits Reabsorption Of Na And Chloride Mainly In The Medullary Portion Of The Ascending Loop Of Henle. Excretion Of Potassium And Ammonia Is Also Increased While Uric Acid Excretion Is Reduced. It Increases Plasma-renin Levels And Secondary Hyperaldosteronism May Result.
Drug Interaction of Furosemide :Furosemide Is Known To Interact With Other Drugs Like Aliskiren, Amikacin (Sulphate), Arbekacin, Caffeine, Calcium Gluconate, Captopril, Carbamazepine, Cefaclor (Monohydrate), Cefazolin, Cefotaxime, Ceftizoxime (Na).
Side effects of Furosemide :Photosensitivity, Skin Rashes, Ototoxicity, Nephrocalcinosis, Hyponatremia, Urinary Retention, Dizziness, Blurred Vision, Hypokalemia, Cardiac Arrhythmias, CHO Intolerance, Hypomagnesemia, Hyperosmolar Non-ketotic Precoma, Deafness, Hypocalcemic Tetany, Ototoxicity, Hypochloremic Alkalosis.


How Furosemide will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Furosemide will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Furosemide

No Studies Found

Generic ( Spironolactone )

Typical use Of Spironolactone :All Forms Of Epilepsy, Congestive Heart Failure, Electrolyte Disorder, For Prophylaxis In Pregnancy, Hirsutism, Hyperaldoesteronism, Hypertension, Myoclonus, Nephrotic Syndrome, Oedema, Oedema And Ascites In Cirrhosis Of The Liver, Parkinson's Disease; Drug-induced Extrapyramidal Symptoms, Primary Hyperaldosteronism, Tobacco Amblyopia And Leber's Optic Atrophy.
Mechanism of action of Spironolactone :Spironolactone Acts On The Distal Renal Tubules As A Competitive Antagonist Of Aldosterone. It Increases The Excretion Of Sodium Chloride And Water While Conserving Potassium And Hydrogen Ions.
Drug Interaction of Spironolactone :Sodium Excretion Effect May Be Inhibited By Aspirin. May Reduce Ulcer-healing Properties Of Carbenoxolone.
Side effects of Spironolactone :Diarrhea, Drowsiness, Dizziness, Mental Confusion.


How Spironolactone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Spironolactone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Spironolactone

No Studies Found