Medicine : Sizonorm Forte

Name:Sizonorm Forte
Type:Tablet
Manufacturer:Crescent Therapeutics Ltd
Generic Use:Chlorpromazine , Trifluoperazine , Trihexiphenidyl
Composition:Chlorpromazine() , Trifluoperazine(5mg) , Trihexiphenidyl(2mg)
Substitutes:peradyl forte , sizonorm forte , peradyl forte , sizonorm forte , peradyl forte , sizonorm forte


Generic ( Chlorpromazine )



Typical use Of Chlorpromazine :Agitated States In The Elderly, Agitation, Agitation And Restlessness In The Elderly, Autism, Childhood Schizophrenia, Conduct Disorder With Hyperactivity, Control Of Agitated States In Elderly Without Confusion, Enhance Permeation Of SC Or IM Inj, Hiccup Due To Gastric Distension In Palliative Care, Induction Of Labour, Intractable Hiccup, Locally Advanced Or Metastatic Pancreatic Cancer, Mania, Muscle Spasm Of Varied Aeitology, NSAID-associated Gastric And Duodenal Ulcers.
Mechanism of action of Chlorpromazine :Chlorpromazine Acts As An Antagonist (blocking Agent) On Different Postsysnaptic Receptors -on Dopaminergic-receptors (subtypes D1, D2, D3 And D4 - Different Antipsychotic Properties On Productive And Unproductive Symptoms), On Serotonergic-receptors (5-HT1 And 5-HT2, With Anxiolytic, Antidepressive And Antiaggressive Properties As Well As An Attenuation Of Extrapypramidal Side-effects, But Also Leading To Weight Gain, Fall In Blood Pressure, Sedation And Ejaculation Difficulties), On Histaminergic-receptors (H1-receptors, Sedation, Antiemesis, Vertigo, Fall In Blood Pressure And Weight Gain), Alpha1/alpha2-receptors (antisympathomimetic Properties, Lowering Of Blood Pressure, Reflex Tachycardia, Vertigo, Sedation, Hypersalivation And Incontinence As Well As Sexual Dysfunction, But May Also Attenuate Pseudoparkinsonism - Controversial) And Finally On Muscarinic (cholinergic) M1/M2-receptors (causing Anticholinergic Symptoms Like Dry Mouth, Blurred Vision, Obstipation, Difficulty/inability To Urinate, Sinus Tachycardia, ECG-changes And Loss Of Memory, But The Anticholinergic Action May Attenuate Extrapyramidal Side-effects).
Drug Interaction of Chlorpromazine :Chlorpromazine Is Known To Interact With Other Drugs Like Alcohol, Belladona, Benzhexol (HCl), Benztropine (Mesylate), Bethanidine (Sulphate), Bovine Insulin, Cimetidine (HCl), Clonidine (HCl), Cyclophosphamide, Debrisoquine (Sulphate), Dexamphetamine (Sulphate), Diazoxide, Disulfiram, Epirubicin, Fosphenytoin, Glibornuride, Gliquidone, Guanethidine, Human Insulin, Imipramine (HCl), Insulin Lispro, Lithium, Metacycline (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Chlorpromazine :Seizures, Blood Dyscrasias, Neuroleptic Malignant Syndrome, Temperature Disorders, Ventricular Arrhythmias, Jaundice, Tachycardia, Hypothermia, Tachypnea, Dizziness, Headache, Drowsiness, Constipation, Insomnia, Skin Rashes, Dry Mouth, Blurred Vision, Allergic Reactions, Akathisia, Weight Gain, Diaphoresis, Acute Dystonia, Skin Pigmentation, Decrease In Libido.

INTERACTIONS OF CHLORPROMAZINE


How Chlorpromazine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chlorpromazine will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Chlorpromazine

No Studies Found






Generic ( Trifluoperazine )



Typical use Of Trifluoperazine :Agitation, Anxiety, Diagnostic Procedures, Enhance Permeation Of SC Or IM Inj, Muscle Spasm Of Varied Aeitology, Nausea And Vomiting, Psychosis, Schizophrenia, Severe Nausea And Vomiting.
Mechanism of action of Trifluoperazine :Trifluoperazine Blocks Postsynaptic Mesolimbic Dopaminergic D1 And D2 Receptors In The Brain; Depresses The Release Of Hypothalamic And Hypophyseal Hormones And Is Believed To Depress The Reticular Activating System Thus Affecting Basal Metabolism, Body Temperature, Wakefulness, Vasomotor Tone, And Emesis.
Drug Interaction of Trifluoperazine :Trifluoperazine Is Known To Interact With Other Drugs Like Adrenaline, Alcohol, Guanethidine, Levodopa, Thyroxine (Na), Trazodone (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictlybe Required.
Side effects of Trifluoperazine :Tardive Dyskinesia, Hypotension, Akathisia, Torticollis, Dystonic Syndrome, Dizziness, Drowsiness, Anorexia,insomnia, Dry Mouth, Blurred Vision, Postural Hypotension, Lassitude, Motor Restlessnes, Dyskinesia, Dystonia.

INTERACTIONS OF TRIFLUOPERAZINE


How Trifluoperazine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Trifluoperazine will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Trifluoperazine

No Studies Found






Generic ( Trihexiphenidyl )



Typical use Of Trihexiphenidyl :Prophylaxis Of Drug-induced Extrapyramidal Symptoms, Idiopathic Parkinsonism.
Mechanism of action of Trihexiphenidyl :Trihexyphenidyl Is A Selective M1 Muscarinic Acetylcholine Receptor Antagonist. Trihexyphenidyl Partially Blocks Cholinergic Activity In The CNS, Which Is Responsible For The Symptoms Of Parkinson's Disease. It Is Also Thought To Increase The Availability Of Dopamine, A Brain Chemical That Is Critical In The Initiation And Smooth Control Of Voluntary Muscle Movement.
Drug Interaction of Trihexiphenidyl :Trihexyphenidyl Is Known To Interact With Other Drugs Like Donepezil, Galantamine, Haloperidol, Pramlintide, Tacrine. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Trihexiphenidyl :Dry Mouth, Blurring Of Vision, Constipation, Urinary Retention, Glaucoma, Confusion, Drowsiness, Restlessness, Hallucinations.

INTERACTIONS OF TRIHEXIPHENIDYL


How Trihexiphenidyl will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Trihexiphenidyl will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Trihexiphenidyl

No Studies Found