Medicine : Simplyone Roto(200mcg)

Name:Simplyone Roto(200mcg)
Type:Capsule
Manufacturer:Cipla Ltd
Generic Use:Ciclesonide , Formoterol
Composition:Ciclesonide(200mcg) , Formoterol(4.5mcg)
Substitutes:simplyone roto(200mcg) , simplyone roto(200mcg)


Generic ( Ciclesonide )



Typical use Of Ciclesonide :Asthma, For The Treatment Of Nasal Symptoms Associated With Seasonal And Perennial Allergic Rhinitis In Adults And Adolescents 12 Years Of Age And Older.
Mechanism of action of Ciclesonide :Ciclesonide Reduces Inflammatory Reaction By Limiting The Capillary Dilatation And Permeability Of The Vascular Structures. These Compounds Restrict The Accumulation Of Polymorphonuclear Leukocytes And Macrophages And Reduce The Release Of Vasoactive Kinins. Corticosteroids May Inhibit The Release Of Arachidonic Acid From Phospholipids, Thereby Reducing The Formation Of Prostaglandins. Ciclesonide Is A Glucocorticoid Receptor Agonist. On Binding, The Corticoreceptor-ligand Complex Translocates Itself Into The Cell Nucleus, Where It Binds To Many Glucocorticoid Response Elements (GRE) In The Promoter Region Of The Target Genes. The DNA Bound Receptor Then Interacts With Basic Transcription Factors, Causing An Increase Or Decrease In Expression Of Specific Target Genes, Including Suppression Of IL2 (interleukin 2) Expression.
Drug Interaction of Ciclesonide :Ciclesonide Is Known To Interact With Other Drugs Like Itraconazole, Ketoconazole, Nelfinavir, Ritonavir, Voriconazole. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Ciclesonide :Bad Taste, Hoarse Voice, Paradoxical Bronchospasm, Rash And Eczema, Dryness, Burning, Inflammation And Irritation At Application Site, Cough After Inhalation.

INTERACTIONS OF CICLESONIDE


How Ciclesonide will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Ciclesonide will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ciclesonide

No Studies Found






Generic ( Formoterol )



Typical use Of Formoterol :Duodenal Ulceration, For Prophylaxis In Pregnancy, Prohylaxis Of Acid Aspiration In Obstetric Patients.
Mechanism of action of Formoterol :Formoterol Stimulates The Intracellular Adenyl Cyclase, The Enzyme That Catalyzes The Conversion Of Adenosine Triphosphate (ATP) To Cyclic-3', 5'-adenosine Monophosphate (cyclic AMP). Increased Cyclic AMP Levels Cause Relaxation Of Bronchial Smooth Muscle And Inhibits The Release Of Pro-inflammatory Mast-cell Mediators Such As Histamine And Leukotrienes.
Drug Interaction of Formoterol :Formoterol Is Known To Interact Withother Drugs Like Quinidine, Disopyramide, Procainamide, Phenothiazines, Antihistamines, MAOI Or TCAs, L-dopa, L-thyroxine, Oxytocin, Alcohol. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Formoterol :Headache, Palpitation, Tachycardia, Insomnia, Tremor, Peripheral Dilatation.

INTERACTIONS OF FORMOTEROL


How Formoterol will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Formoterol will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Formoterol

No Studies Found