Medicine : Sembrina (250mg)

Name:Sembrina (250mg)
Type:Tablet
Manufacturer:Sanofi India Ltd (aventis)
Generic Use:Methyldopa
Composition:Methyldopa(250 Mg)
Substitutes:dopagyt (250mg) , methyl dopa(250mg) , alphadopa (250mg) , sembrina (250mg) , gynapres (250mg) , emdopa (250mg) , aldopam (250mg) , alphadopa tab


Generic ( Methyldopa )



Typical use Of Methyldopa :Mild To Moderate Hypertension.
Mechanism of action of Methyldopa :Methyldopa Stimulates ?2-adrenoceptors Which Results In Reduced Sympathetic Tone And Fall In BP.
Drug Interaction of Methyldopa :The Use Of Amantadine (Symmetrel), Benztropine (Cogentin), Procyclidine (Kemadrin), Or Trihexyphenidyl (Artane) With Carbidopa-levodopa Can Enhance The Anti- Parkinson's Effects Of Levodopa. Droperidol, Haloperidol (Haldol), Loxapine (Loxitane), Metoclopramide(Reglan), Phenothiazines Such As Prochlorperazine (Thorazine); Thioxanthenes As Thiothixene (Navane) Inhibit Dopamine In The Brain. These Drugs, Therefore, Can Worsen Parkinson's Disease And Reverse The Beneficial Effects Of Levodopa. Methyldopa (Aldomet) And Reserpine Also Can Interfere With The Beneficial Actions Of Carbidopa-levodopa And Can Increase The Risk Of Side Effects. The Occurrence Of Postural Hypotension (reduced Blood Pressure When Standing From A Sitting Or Lying Down Position) May Increase When Carbidopa-levodopa Is Combined With Drugs That Reduce Blood Pressure.Phenytoin (Dilantin) Can Increase The Break-down Of Carbidopa-levodopa, Reducing Its Effectiveness. Use Of Carbidopa-levodopa With Monoamine Oxidase Inhibitors (MAOI's) Antidepressants, For Example, Isocarboxazid (Marplan), Phenelzine (Nardil), Tranylcypromine (Parnate), And Procarbazine (Matulane), Can Result In Severe And Dangerous Elevations In Blood Pressure. MAOI's Should Be Stopped 2-4 Weeks Before Starting Carbidopa-levodopa Therapy.
Side effects of Methyldopa :Drug Fever, Mental Depression, Anxiety, Nightmares, Drowsiness, Headache; Dry Mouth; Orthostatic Hypotension, Sinus Bradycardia, Sodium Retention, Sexual Dysfunction, Gynaecomastia, Hyperprolactinaemia, Thrombocytopenia, Positive Coombs' Test, Transient Leukopenia Or Granulocytopenia, Cholestasis. Hepatic Necrosis, Haemolytic Anaemia.

INTERACTIONS OF METHYLDOPA


How Methyldopa will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Methyldopa will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Methyldopa

No Studies Found