Medicine : Salazar Tablet

Name:Salazar Tablet
Type:Tablet
Manufacturer:Cadila Pharmaceuticals Ltd
Generic Use:Sulfasalazine
Composition:Sulfasalazine(500 Mg)
Substitutes:salazar tablet


Generic ( Sulfasalazine )



Typical use Of Sulfasalazine :Ulcerative Colitis And Inflammatory Bowel Disease.
Mechanism of action of Sulfasalazine :The Mode Of Action Of Sulfasalazine Or Its Metabolites, 5-aminosalicylic Acid (5-ASA) And Sulfapyridine (SP), Is Still Under Investigation, But May Be Related To The Anti-inflammatory And/or Immunomodulatory Properties That Have Been Observed In Animal And In Vitro Models, To Its Affinity For Connective Tissue, And/or To The Relatively High Concentration It Reaches In Serous Fluids, The Liver And Intestinal Walls, As Demonstrated In Autoradiographic Studies In Animals. In Ulcerative Colitis, Clinical Studies Utilizing Rectal Administration Of Sulfasalazine, SP And 5-ASA Have Indicated That The Major Therapeutic Action May Reside In The 5-ASA Moiety. The Relative Contribution Of The Parent Drug And The Major Metabolites In Rheumatoid Arthritis Is Unknown.
Drug Interaction of Sulfasalazine :Sulfasalazine May Cause Reduced Absorption Of Folic Acid And Digoxin (Lanoxin). Reduced Folic Acid Absorption May Cause Folic Acid Deficiency And Result In Anemia. Reduced Digoxin Absorption May Reduce The Effectiveness Of Digoxin. Sulfapyridine (a Byproduct Of Sulfasalazine) Is A Sulfonamide, And Sulfonamides Increase Blood Levels Ofmethotrexate (Rheumatrex, Trexall), Resulting In Increased Methotrexate Toxicity. Conversely, Methotrexate Can Increase The Occurrence Of The Anemia Caused By Sulfonamides Because Methotrexate Also Causes Folic Acid Deficiency. Sulfonamides Can Increase The Risk Of Kidney Damage From Cyclosporine By An Unknown Mechanism. They Also May Increase The Blood Glucose Lowering Effect Of Oral Anti-diabetic Drugs And Potentially Cause Excessive Reductions In Blood Sugar (hypoglycemia) By Decreasing Elimination Of Anti-diabetic Drugs By The Liver And Elevating The Levels Of The Anti-diabetic Drugs In The Blood. Combining 5-ASA With Drugs That Affect Kidney Function Such As Nonsteroidal Antiinflammatory Drugs, For Example, Ibuprofen (Advil), May Increase The Likelihood Of Kidney Dysfunction. Concurrent Use Of 5-ASA And 6-mercaptopurine Or Azathioprine (Imuran) May Increase The Likelihood Of Blood Disorders. 5-ASA May Increase The Blood Thinning Effect Of Warfarin(Coumadin).
Side effects of Sulfasalazine :Headache, Fatigue, Abdominal Pain, Dysuria, Malaise, Glossitis, Urinary RetentionX, Epistaxis, Urinary Retention.

INTERACTIONS OF SULFASALAZINE


How Sulfasalazine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Sulfasalazine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Sulfasalazine

No Studies Found