Medicine : Rimactazid 450/(300mg)

Name:Rimactazid 450/(300mg)
Type:Tablet
Manufacturer:Novartis Pharmaceuticals Ltd
Generic Use:Isoniazid , Rifampicin
Composition:Isoniazid(300mg) , Rifampicin(450mg)
Substitutes:bicox (450mg) , mycocox , montonex forte , rimactazid 450/(300mg) , rimactazid (450/300mg tab 10mg) , coxrid , isokoxi800 (800) , myconex (600) , myconex800 (800) , radibutolin , akt2kit (2) , akt2 (2) , cadirifa tab , bicox (450mg) , mycocox , montonex forte , rimactazid 450/(300mg) , rimactazid (450/300mg tab 10mg) , coxrid , isokoxi800 (800) , myconex (600) , myconex800 (800) , radibutolin , akt2kit (2) , akt2 (2) , cadirifa tab


Generic ( Isoniazid )



Typical use Of Isoniazid :Acute Leukemia, Mycobacterial Infection, Prophylaxis Of TB, Tuberculosis, Vestibular Disorders.
Mechanism of action of Isoniazid :Isoniazid Is A Prodrug And Must Be Activated By Bacterial Catalase. Specficially, Activation Is Associated With Reduction Of The Mycobacterial Ferric KatG Catalase-peroxidase By Hydrazine And Reaction With Oxygen To Form An Oxyferrous Enzyme Complex. Once Activated, Isoniazid Inhibits The Synthesis Of Mycoloic Acids, An Essential Component Of The Bacterial Cell Wall. At Therapeutic Levels Isoniazid Is Bacteriocidal Against Actively Growing Intracellular And Extracellular Mycobacterium Tuberculosis Organisms. Specifically Isoniazid Inhibits InhA, The Enoyl Reductase From Mycobacterium Tuberculosis, By Forming A Covalent Adduct With The NAD Cofactor. It Is The INH-NAD Adduct That Acts As A Slow, Tight-binding Competitive Inhibitor Of InhA.
Drug Interaction of Isoniazid :Your Doctor Or Pharmacist May Already Be Aware Of Any Possible Drug Interactions And May Be Monitoring You For Them. Do Not Start, Stop, Or Change The Dosage Of Any Medicine Before Checking With Your Doctor Or Pharmacist First.
Side effects of Isoniazid :Nausea, Vomiting, Tachycardia, Convulsions, Coma, Seizures, Urinary Retention, Dizziness, Hyperreflexia, Slurred Speech.

INTERACTIONS OF ISONIAZID


How Isoniazid will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Isoniazid will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Isoniazid

No Studies Found






Generic ( Rifampicin )



Typical use Of Rifampicin :Epilepsy (monotherapy), Iron-deficiency Anaemia With Chronic Renal Failure, Leprosy, Meningitis, Meningitis Prophylaxis, Mycobacterial Infection, Paget's Disease Of Bone, Tuberculosis, Urinary Tract Infection
Mechanism of action of Rifampicin :Rifampicin Acts Via The Inhibition Of DNA-dependent RNA Polymerase, Leading To A Suppression Of RNA Synthesis And Cell Death.
Drug Interaction of Rifampicin :Epilepsy (monotherapy), Iron-deficiency Anaemia With Chronic Renal Failure, Leprosy, Meningitis, Meningitis Prophylaxis, Mycobacterial Infection, Paget's Disease Of Bone, Tuberculosis, Urinary Tract Infection
Side effects of Rifampicin :Nausea, Vomiting, Anorexia, Abdominal Discomfort, Orange Coloration Of Secretions.

INTERACTIONS OF RIFAMPICIN


How Rifampicin will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Rifampicin will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Rifampicin

No Studies Found