Medicine : Rasotan Sa(5)

Name:Rasotan Sa(5)
Type:Tablet
Manufacturer:Emcure Pharmaceuticals Ltd
Generic Use:Olmesartan Medoxomil , Amlodipine Besylate
Composition:Olmesartan Medoxomil(20 Mg) , Amlodipine Besylate(5 Mg)
Substitutes:rasotan sa , rasotan sa(5) , rasotan sa , rasotan sa(5)


Generic ( Olmesartan Medoxomil )



Typical use Of Olmesartan Medoxomil :Hypertension, Diabetic Nephropathy, Heart Failure.
Mechanism of action of Olmesartan Medoxomil :Olmesartan Medoxomil Is An ARB That Selectively Inhibits The Binding Of Angiotensin II To AT1, Which Is Found In Many Tissues Such As Vascular Smooth Muscle And The Adrenal Glands. This Effectively Inhibits The AT1-mediated Vasoconstrictive And Aldosterone-secreting Effects Of Angiotensin II And Results In A Decrease In Vascular Resistance And Blood Pressure. Olmesartan Is Selective For AT1 And Has A 12,500 Times Greater Affinity For AT1 Than The AT2 Receptor.
Drug Interaction of Olmesartan Medoxomil :Olmesartan Medoxomil Is Known To Interact With Other Drugs Like ACE Inhibitors, Potassium-sparing Diuretics, Potassium Salts, And Drugs That May Increase Serum Potassium (e.g. Ciclosporin, Eplerenone), Concomitant Use With NSAIDs. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Olmesartan Medoxomil :Headache, Diarrhea, Pharyngitis, Hematuria, Rhinitis, Bronchitis, Sinusitis, Hyperglycemia.

INTERACTIONS OF OLMESARTAN MEDOXOMIL


How Olmesartan Medoxomil will impact on Pregnancy ?

There Are No Studies Available Regarding Its Use During Pregnancy. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Olmesartan Medoxomil will impact during lactation(breastfeeding) ?

There Are No Studies Available Regarding Its Use During Lactation. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Olmesartan Medoxomil

No Studies Found






Generic ( Amlodipine Besylate )



Typical use Of Amlodipine Besylate :Mild To Moderate Hypertension.Angina Pectoris.Prinzmetals Angina.
Mechanism of action of Amlodipine Besylate :Amlodipine Relaxes Peripheral And Coronary Vascular Smooth Muscle. It Produces Coronary Vasodilation By Inhibiting The Entry Of Ca Ions Into The Voltage-sensitive Channels Of The Vascular Smooth Muscle And Myocardium During Depolarisation. It Also Increases Myocardial O2 Delivery In Patients With Vasospastic Angina.
Drug Interaction of Amlodipine Besylate :Increased Metabolism With Rifampin. Reduced Hypotensive Effect With Calcium. Potentiates Effects Of Thiazide Diuretics And ACE Inhibitors. Avoid Combination With ?-blockers In Patients With Markedly Impaired Left Ventricular Function. May Increase Serum Levels Of CYP1A2 Substrates E.g. Aminophylline, Fluvoxamine, Ropinirole. CYP3A4 Inhibitors (e.g. Clarithromycin, Doxycycline, Isoniazid, Nicardipine) May Increase The Effects Of Amlodipine. Additive BP-lowering Effects When Used With Sildenafil, Tadalafil Or Vardenafil.
Side effects of Amlodipine Besylate :Headache, Peripheral Oedema, Fatigue, Somnolence, Nausea, Abdominal Pain, Flushing, Dyspepsia, Palpitations, Dizziness. Rarely Pruritus, Rash, Dyspnoea, Asthenia, Muscle Cramps. Potentially Fatal: Hypotension, Bradycardia, Conductive System Delay And CCF.

INTERACTIONS OF AMLODIPINE BESYLATE


How Amlodipine Besylate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Amlodipine Besylate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Amlodipine Besylate

No Studies Found