Medicine : Quadrajel (15gm)

Name:Quadrajel (15gm)
Type:Cream
Manufacturer:Fourrts India Laboratories Pvt Ltd
Generic Use:Chlorhexidine Gluconate , Lidocaine Hydrochloride , Metronidazole Benzoate
Composition:Chlorhexidine Gluconate(1%w /w) , Lidocaine Hydrochloride(2%w /w) , Metronidazole Benzoate(1%w /w)
Substitutes:quadrajel (15gm) , quadrajel (15gm) , quadrajel (15gm)


Generic ( Chlorhexidine Gluconate )


Typical use Of Chlorhexidine Gluconate :Abrasion, Bladder Irrigation, Bleeding, Burns, Cuts, Gingivitis, Infected Cracked Skin, Minor Burns, Minor Scalds, Pleural And Peritoneal Irrigation, Skin Infections, Skin Lesions, Sunburn Blisters, Ulcers, Urethral Infection.
Mechanism of action of Chlorhexidine Gluconate :Chlorhexidine's Antimicrobial Effects Are Associated With The Attractions Between Chlorhexidine (cation) And Negatively Charged Bacterial Cells. After Chlorhexidine Is Absorpted Onto The Organism's Cell Wall, It Disrupts The Integrity Of The Cell Membrane And Causes The Leakage Of Intracellular Components Of The Organisms.
Drug Interaction of Chlorhexidine Gluconate :Chlorhexidine Is Known To Interact With Other Drugs Like Povidone-iodine. These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Chlorhexidine Gluconate :Shortness Of Breadth, Hemolysis, Hypersensitivity Reactions, Photophobia, Slurred Speech, Allergic Skin Reactions, Nausea, Vomiting, Allergic Reactions, Photosensitivity, Skin Irritation, Skin Sensitization, Irritation Of Sensitive Tissues, Dermatitis, Taste Disturbances, Teeth Discoloration.

INTERACTIONS OF CHLORHEXIDINE GLUCONATE

How Chlorhexidine Gluconate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chlorhexidine Gluconate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Chlorhexidine Gluconate

No Studies Found





Generic ( Lidocaine Hydrochloride )


Typical use Of Lidocaine Hydrochloride :Anesthesia, Caudal Anaesthesia, Epidural Anaesthesia, Headache Associated With Migraine, Infilteration Anaesthesia, Intravenous Regional Anaesthesia, Local Anaesthesia, Neuropathic Pain, Obstetric Anaesthesia, Severe Hiccup, Toothache, Transtracheal Anaesthesia, Urethral Anesthesia.
Mechanism of action of Lidocaine Hydrochloride :Lidocaine Stabilizes The Neuronal Membrane By Inhibiting The Ionic Fluxes Required For The Initiation And Conduction Of Impulses Thereby Effecting Local Anesthetic Action. Lidocaine Alters Signal Conduction In Neurons By Blocking The Fast Voltage Gated Sodium (Na+) Channels In The Neuronal Cell Membrane That Are Responsible For Signal Propagation. With Sufficient Blockage The Membrane Of The Postsynaptic Neuron Will Not Depolarize And Will Thus Fail To Transmit An Action Potential. This Creates The Anaesthetic Effect By Not Merely Preventing Pain Signals From Propagating To The Brain But By Aborting Their Birth In The First Place.
Drug Interaction of Lidocaine Hydrochloride :Lidocaine (HCl) Is Known To Interact With Other Drugs Like Alcuronium (Cl), Amphotericin B, Amprenavir, Atracurium (Besylate), Cimetidine (HCl), Edrophonium (Cl), Enflurane, Fosphenytoin, Halothane, Nadolol, Oxprenolol (HCl), Pentazocine, Propafenone (HCl), Propranolol (HCl), Rocuronium (Br), Suxamethonium (Cl), Timolol (Maleate), Tocainide (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Lidocaine Hydrochloride :Allergy, Hypotension, Bronchospasm, Coma, Seizures, Hypertension, Tissue Necrosis, Angina, Sinus Bradycardia, Respiratory Depression, Blurred Vision, Malignant Hyperthermia, Neonatal Depression, Cardiovascular Depression, Dizziness, Headache, Drowsiness, Nausea, Vomiting, Anxiety, Restlessness, Palpitation, Nervousness, Tinnitus, Abdominal Pain, Confusion, Tremor, Nystagmus.

INTERACTIONS OF LIDOCAINE HYDROCHLORIDE

How Lidocaine Hydrochloride will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Lidocaine Hydrochloride will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Lidocaine Hydrochloride

No Studies Found





Generic ( Metronidazole Benzoate )


Typical use Of Metronidazole Benzoate :Acute Dental Infections, Acute Ulcerative Gingivitis, Amoebiasis, Anaerobic Bacterial Infection, Anaerobic Infections, Dysentery, Giardiasis, Lung Cancer And Pancreatic Cancer, Pelvic Inflammatory Disease, Protozoa Infection.
Mechanism of action of Metronidazole Benzoate :Metronidazole Is A Prodrug. Unionized Metronidazole Is Selective For Anaerobic Bacteria Due To Their Ability To Intracellularly Reduce Metronidazole To Its Active Form. This Reduced Metronidazole Then Covalently Binds To DNA, Disrupt Its Helical Structure, Inhibiting Bacterial Nucleic Acid Synthesis And Resulting In Bacterial Cell Death.
Drug Interaction of Metronidazole Benzoate :Acute Psychoses Or Confusion With Disulfiram. Additive/synergistic Effect With Other Antimicrobials.
Side effects of Metronidazole Benzoate :Weakness, Dizziness, Vertigo, Headache, Anorexia, Diarrhea, Palpitation, Insomnia, Dry Mouth, Maculopapular Rash, Rashes.

INTERACTIONS OF METRONIDAZOLE BENZOATE

How Metronidazole Benzoate will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Metronidazole Benzoate will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Metronidazole Benzoate

No Studies Found