Medicine : Powergyl Syp.(30ml)

Name:Powergyl Syp.(30ml)
Manufacturer:Cipla Ltd
Generic Use:Metronidazole , Norfloxacin
Composition:Metronidazole(500mg) , Norfloxacin(400mg/5mL)
Substitutes:powergyl norfmet , powergyl syp.(30ml) , powergyl norfmet , powergyl syp.(30ml)

Generic ( Metronidazole )

Typical use Of Metronidazole :Amoebiasis, Giardiasis, Trichomonas Vaginitis, Anaerobic Infections, Ulcerative Gingivitis.Eradication Of H.pylori Associated With Peptic Ulcer Disease.Antibiotic-associated Coulitis. Trichomoniasis, Balantidiasis, Blastocyatis Hominis Infection. Adjunct To Treatment Of Chronic Periodontal Infections. Rosacea.
Mechanism of action of Metronidazole :Metronidazole Is Converted To Reduction Products That Interact With DNA To Cause Destruction Of Helical DNA Structure And Strand Leading To A Protein Synthesis Inhibition And Cell Death In Susceptible Organisms. It Is Effective Against A Wide Range Of Organisms Including E. Histolytica, T. Vaginalis, Giardia, Anaerobes E.g. Bacterioides Sp, Fusobacterium Sp, Clostridium Sp.
Drug Interaction of Metronidazole :Acute Psychoses Or Confusion With Disulfiram. It Has Synergistic Effect With Other Antimicrobials. Effects Reduced With Phenobarbital Or Phenytoin. Disulfiram-like Reaction With Alcohol. Increased Risk Of Adverse Effects Of Coumarin Anticoagulants, Phenytoin, Lithium, Ciclosporin, Fluorouracil. Increased Risk Of Neurological Effects With Cimetidine.
Side effects of Metronidazole :GI Disturbances E.g. Nausea, Unpleasant Metallic Taste, Vomiting, Diarrhoea Or Constipation. Furred Tongue, Glossitis, And Stomatitis Due To Overgrowth Of Candida. Rarely, Antibiotic-associated Colitis. Weakness, Dizziness, Ataxia, Headache, Drowsiness, Insomnia, Changes In Mood Or Mental State. Numbness Or Tingling In The Extremities, Epileptiform Seizures (high Doses Or Prolonged Treatment). Transient Leucopenia And Thrombocytopenia. Hypersensitivity Reactions. Anaphylaxis.


How Metronidazole will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Metronidazole will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Metronidazole

No Studies Found

Generic ( Norfloxacin )

Typical use Of Norfloxacin :To Treat Urinary Tract Infections, Infections Of The Stomach Or Intestines (travelers’ Diarrhea), Sexually Transmitted Diseases (gonorrhea), Genital Infection, Prostate Gland Infections And Eye Infection.
Mechanism of action of Norfloxacin :Norfloxacin Belongs To A Group Of Antibiotics Called Fluoroquinolones And Kills A Wide Range Of Infection Causing Bacteria Both Gram Positive And Gram Negative. It Acts By Inhibiting Enzymes (DNA Gyrase And Topoisomerase IV) Involved In DNA Processes That Are Essential For Bacterial Growth And Survival Thereby Killing The Bacteria.
Drug Interaction of Norfloxacin :Norfloxacin May Interact With Caffeine, Clozapine, Ropinirole, Tacrine, Theophylline, Tizanidine, Dexamethasone, Methylprednisolone, Prednisone, Cyclosporine, Warfarin, Glyburide And Probenecid. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Norfloxacin :Dizziness, Urge To Vomit (nausea), Vomiting, Headache, Indigestion, Dry Mouth, Weakness, Cramps In The Abdomen, Back Pain, Severe Stomach Pain, Symptoms Of Severe Sunburn Such As Redness, Itching, Swelling Or Blistering; Constipation, Tenderness, Swelling Of Muscles Joints, Infections Of Liver, Signs Of Anaemia, Such As Tiredness, Being Short Of Breath And Looking Pale.


How Norfloxacin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Norfloxacin will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Norfloxacin

No Studies Found