Generic ( Phenobarbitone )

Typical use Of Phenobarbitone :Benign Febrile Convulsions Of Infancy, Epilepsy, Seizures, Short-term Treatment Of Severe Congestive Heart Failure, Status Epilepticus.
Mechanism of action of Phenobarbitone :Phenobarbital Acts On GABA A Receptors, Increasing Synaptic Inhibition. Phenobarbital May Also Inhibit Calcium Channels, Resulting In A Decrease In Excitatory Transmitter Release. The Sedative-hypnotic Effects Of Phenobarbital Are Likely The Result Of Its Effect On The Polysynaptic Midbrain Reticular Formation, Which Controls CNS Arousal.
Drug Interaction of Phenobarbitone :Phenobarbitone Is Known To Interact With Other Drugs Like Abacavir, Alcohol, Alfacalcidol, Amoxapine, Bupropion (HCl), Calcifediol, Carbamazepine, Carmustine, Chloramphenicol, Chlorpropamide, Clonazepam, Corticotropin, Cyclosporin A, Desogestrel, Dexamethasone, Dexamphetamine (Sulphate), Dextropropoxyphene, Di-Iodohydroxyquinoline, Diazepam, Digitoxin, Diltiazem (HCl), Dimemorfan Phosphate, Dipyrone, Disopyramide, Doxycycline, Dydrogesterone, Ephedrine, Estazolam, Estradiol (Valerate), Ethinyloestradiol, Ethosuximide, Ethynodiol (Diacetate), Flunisolide, Fosphenytoin, Gallopamil, Gestodene, Griseofulvin. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Phenobarbitone :Ataxia, Confusion, Aggression, Irritability, Nystagmus, Mental Disturbances, Agranulocytosis, Aplastic Anemia, Exfoliative Dermatitis, Hepatitis, Skin Rashes, Erythema, Morbiliform.


How Phenobarbitone will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Phenobarbitone will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Phenobarbitone

No Studies Found