Medicine : Pantop Hp

Name:Pantop Hp
Type:Tablet
Manufacturer:Aristo Pharmaceuticals Pvt Ltd
Generic Use:Clarithromycin , Metronidazole , Pantoprazole
Composition:Clarithromycin(250mg) , Metronidazole(400Mg) , Pantoprazole(40mg)
Substitutes:pantop hp , pantop plus , pantop hp , pantop plus , pantop hp , pantop plus


Generic ( Clarithromycin )


Typical use Of Clarithromycin :URTI, Pharyngitis And Sinusitis, LRTI, Bronchitis And Pneumonia, Skin And Soft Tissue Infection. H.Pylori Infection.Infection Due To Mycobacterium Avium Complex (MAC).
Mechanism of action of Clarithromycin :Clarithromycin Is First Metabolized To 14-OH Clarithromycin, Which Is Active And Works Synergistically With Its Parent Compound. Like Other Macrolides, It Then Penetrates Bacteria Cell Wall And Reversibly Binds To Domain V Of The 23S Ribosomal RNA Of The 50S Subunit Of The Bacterial Ribosome, Blocking Translocation Of Aminoacyl Transfer-RNA And Polypeptide Synthesis. Clarithromycin Also Inhibits The Hepatic Microsomal CYP3A4 Isoenzyme And P-glycoprotein, An Energy-dependent Drug Efflux Pump.
Drug Interaction of Clarithromycin :Clarithromycin Is Known To Interact With Other Drugs Like Alprazolam, Artesunate, Astemizole, Carbamazepine, Cimetidine (HCl), Cisapride, Cyclosporin A, Digoxin, Dihydroergotamine (Mesylate), Disopyramide, Ergotamine (Tartrate), Erlotinib, Fluoxetine (HCl), Isosorbide (Dinitrate), Loratadine, Lorazepam, Lovastatin.
Side effects of Clarithromycin :Pseudomembranous Colitis, Renal Failure, Interstitial Nephritis, Headache, Nausea, Vomiting, Diarrhea, Abdominal Pain, Phlebitis, Glossitis, Stomatitis.

INTERACTIONS OF CLARITHROMYCIN

How Clarithromycin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Clarithromycin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Clarithromycin

No Studies Found





Generic ( Metronidazole )


Typical use Of Metronidazole :Amoebiasis, Giardiasis, Trichomonas Vaginitis, Anaerobic Infections, Ulcerative Gingivitis.Eradication Of H.pylori Associated With Peptic Ulcer Disease.Antibiotic-associated Coulitis. Trichomoniasis, Balantidiasis, Blastocyatis Hominis Infection. Adjunct To Treatment Of Chronic Periodontal Infections. Rosacea.
Mechanism of action of Metronidazole :Metronidazole Is Converted To Reduction Products That Interact With DNA To Cause Destruction Of Helical DNA Structure And Strand Leading To A Protein Synthesis Inhibition And Cell Death In Susceptible Organisms. It Is Effective Against A Wide Range Of Organisms Including E. Histolytica, T. Vaginalis, Giardia, Anaerobes E.g. Bacterioides Sp, Fusobacterium Sp, Clostridium Sp.
Drug Interaction of Metronidazole :Acute Psychoses Or Confusion With Disulfiram. It Has Synergistic Effect With Other Antimicrobials. Effects Reduced With Phenobarbital Or Phenytoin. Disulfiram-like Reaction With Alcohol. Increased Risk Of Adverse Effects Of Coumarin Anticoagulants, Phenytoin, Lithium, Ciclosporin, Fluorouracil. Increased Risk Of Neurological Effects With Cimetidine.
Side effects of Metronidazole :GI Disturbances E.g. Nausea, Unpleasant Metallic Taste, Vomiting, Diarrhoea Or Constipation. Furred Tongue, Glossitis, And Stomatitis Due To Overgrowth Of Candida. Rarely, Antibiotic-associated Colitis. Weakness, Dizziness, Ataxia, Headache, Drowsiness, Insomnia, Changes In Mood Or Mental State. Numbness Or Tingling In The Extremities, Epileptiform Seizures (high Doses Or Prolonged Treatment). Transient Leucopenia And Thrombocytopenia. Hypersensitivity Reactions. Anaphylaxis.

INTERACTIONS OF METRONIDAZOLE

How Metronidazole will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Metronidazole will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Metronidazole

No Studies Found





Generic ( Pantoprazole )


Typical use Of Pantoprazole :Pantoprazole Is Used For Treatment Of Ulcers In The Stomach And Small Intestine, Heart-burn, Inflammation Of The Food-pipe Due To Regurgitation Of Stomach Acid, Prevention Of Ulcers In Stomach And Small Intestine Caused By Non-steroidal Anti-inflammatory Drugs (pain-killers), And Zollinger-Ellison Syndrome (condition Associated With Excessive Secretion Of Acid In The Stomach).
Mechanism of action of Pantoprazole :Pantoprazole Is A Proton Pump Inhibitor (PPI) That Blocks The Acid-producing Pump In The Wall Of The Stomach. By Blocking This Pump, The Production Of Acid Is Decreased, And This Allows The Stomach, Small Intestine And Food Pipe To Heal.
Drug Interaction of Pantoprazole :Pantoprazole May Reduce The Absorption Of Active Substances Whose Availability In Blood Is Dependent On The Gastric PH (e.g. Ketoconazole, Itraconazole, Posaconazole, Erlotinib, Atazanavircan). Administration Of Pantoprazole Along With Atazanavir Or Nelfinavir (anti-HIV Drugs) Can Result In Reduction In The Blood Levels Of These Drugs. Pantoprazole When Administered With Warfarin And Coumarin Anticoagulants Can Increase The Thinning Of The Blood And Cause Bleeding. Concomitant Use Of High Dose Methotrexate And Pantoprazole May Increase Blood Levels Of Methotrexates. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Pantoprazole :Urge To Vomit (nausea), Vomiting, Constipation, Excessive Passing Of Gas, Headache, Diarrhea, Muscle Pain, Joint Pain, And Skin Rashes.

INTERACTIONS OF PANTOPRAZOLE

How Pantoprazole will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Pantoprazole will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Pantoprazole

No Studies Found