Medicine : Ocupol Eye Drops

Name:Ocupol Eye Drops
Type:Drop
Manufacturer:Centaur Pharmaceuticals Pvt Ltd
Generic Use:Chloramphenicol , Polymyxin B Sulphate
Composition:Chloramphenicol() , Polymyxin B Sulphate(5000 IU)
Substitutes:ocupol eye drops , ocupol eye drops


Generic ( Chloramphenicol )



Typical use Of Chloramphenicol :Enteric Fever (Typhoid And Para Typhoid).H.Influenzae Meningitis. Anaerobic Infections, Intraocular Infections, Urinary Tract Infections, Conjunctivitis, External Ear Infections.Corneal Ulcer, Bacterial Conjunctivitis, Trachoma, Ocular Infections.Otitis Externa, Chronic Otitis Media. Pre And Post Antral Or Mastoid Surgery.
Mechanism of action of Chloramphenicol :Chloramphenicol Is Lipid-soluble, Allowing It To Diffuse Through The Bacterial Cell Membrane. It Then Reversibly Binds To The L16 Protein Of The 50S Subunit Of Bacterial Ribosomes, Where Transfer Of Amino Acids To Growing Peptide Chains Is Prevented (perhaps By Suppression Of Peptidyl Transferase Activity), Thus Inhibiting Peptide Bond Formation And Subsequent Protein Synthesis.
Drug Interaction of Chloramphenicol :Chloramphenicol Is Known To Interact With Other Drugs Like Amoxicillin, Ampicillin, Ascorbic Acid, Azlocillin (Na), Bacampicillin, Benzathine Penicillin, Carbenicillin (Na), Chlorpropamide, Chymotrypsin, Cimetidine (HCl), Ciprofloxacin, Cloxacillin, Clozapine, Colistin (Sulphate & Sulphomethate Na), Cyanocobalamin, Cyclophosphamide, Dicloxacillin (Na), Ethinyloestradiol, Floxacillin (Na), Fosphenytoin, Estodene, Glibornuride, Gliquidone, Hydroxocobalamin, Ichthammol, Iron Dextran, Iron Salts, Iron Sorbitol, Mecillinam, Mecobalamin, Nafcillin, Oxacillin, Paracetamol, Phenobarbitone, Phenytoin (Na), Piperacillin (Na),pivmecillinam (HCl), Primidone, Procaine Penicillin, Promethazine (HCl),rifampicin, Sulfapyridine, Tolbutamide, Warfarin (Na).
Side effects of Chloramphenicol :Encephalopathy, Pseudomembranous Colitis, Anemia, Urticaria, Anemia, Thrombocytopenia, Hepatitis, Ototoxicity, Peripheral Neuropathy, Optic Neuritis, Hemolytic Reactions, Interstitial Nephritis, Headache, Nausea, Vomiting, Maculopapular Rash, Stomatitis, Confusion, Pruritus, Depression, Glossitis, Delirium, Transient Stinging.

INTERACTIONS OF CHLORAMPHENICOL


How Chloramphenicol will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chloramphenicol will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Chloramphenicol

No Studies Found






Generic ( Polymyxin B Sulphate )



Typical use Of Polymyxin B Sulphate :Susceptible Infections, Ocular Infections, Otic Infections, Skin Infections.
Mechanism of action of Polymyxin B Sulphate :Polymyxin B Sulfate Has A Bactericidal Action Against Almost All Gram-negative Bacilli Except The Proteus Group. Polymyxin B Sulfate Interacts With The Lipopolysaccharide Of The Cytoplasmic Outer Membrane Of Gram-negative Bacteria, Altering Membrane Permeability And Causing Cell Death.
Drug Interaction of Polymyxin B Sulphate :Polymyxin B Sulfate Is Known To Interact With Other Drugs Like Vancomycin, Cefalotin, Aminoglycosides. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Polymyxin B Sulphate :Muscle Weakness, Ataxia, Confusion, Drowsiness, Psychoses, Convulsions, Coma, Neuromuscular Blockade Characterized By Respiratory Paralysis And Apoea, Acute Interstitial Nephritis, Nausea, Vomiting, Electrolyte Imbalance, Topical: Hypersensitivity Eg, Macular Rashes, Risk Of Systemic Toxicity If Applied To Large Areas Of Broken Skin, Otic: Ototoxicity, Stinging And Burning Sensation.

INTERACTIONS OF POLYMYXIN B SULPHATE


How Polymyxin B Sulphate will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Polymyxin B Sulphate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Polymyxin B Sulphate

No Studies Found