Medicine : Obrasone

Name:Obrasone
Type:Drop
Manufacturer:Zydus Cadila
Generic Use:Benzalkonium Chloride , Dexamethasone , Tobramycin
Composition:Benzalkonium Chloride(0.0001w/v) , Dexamethasone(0.001W/V) , Tobramycin(0.003W/V)
Substitutes:obrasone , obrasone , obrasone


Generic ( Benzalkonium Chloride )



Typical use Of Benzalkonium Chloride :Bladder Irrigation, Ear, Eye, Nose And Throat Irrigation, Gingivitis, Perodontal Diseases, Preoperative Disinfection Of Unbroken Skin, Stomatitis, Thrush, Tonsillitis, Urethral Irrigation.
Mechanism of action of Benzalkonium Chloride :The Mode Of Action Of Benzalkonium Chloride Appears To Be Associated With The Effect On The Cytoplasmic Membrane, Which Controls Cell Permeability.
Drug Interaction of Benzalkonium Chloride :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Benzalkonium Chloride : Death, Vomiting, Convulsions, Coma, Collapse, Restlessness, Muscular Weakness, Cyanosis, Dyspnea, Apprehension, Paralysis Of Respiratory Muscle, Allergic Contact Dermatitis.

INTERACTIONS OF BENZALKONIUM CHLORIDE


How Benzalkonium Chloride will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Benzalkonium Chloride will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Benzalkonium Chloride

No Studies Found






Generic ( Dexamethasone )



Typical use Of Dexamethasone :Anorexia In Palliative Care, Congenital Adrenal Hyperplasia, Dyspnoea, Dyspnoea In Palliative Care, Headache Due To Raised Intracranial Pressure In Palliative Care, Nausea And Vomiting (chemotherapy Induced), Pain Due To Nerve Compression In Palliative Care, Raised Intracranial Pressure, Respiratory Distress Syndrome, Shock, Suppression Of Inflammatory And Allergic Disorders.
Mechanism of action of Dexamethasone :Dexamethasone Is A Glucocorticoid Agonist. Unbound Dexamethasone Crosses Cell Membranes And Binds With High Affinity To Specific Cytoplasmic Glucocorticoid Receptors. This Complex Binds To DNA Elements (glucocorticoid Response Elements) Which Results In A Modification Of Transcription And, Hence, Protein Synthesis In Order To Achieve Inhibition Of Leukocyte Infiltration At The Site Of Inflammation, Interference In The Function Of Mediators Of Inflammatory Response, Suppression Of Humoral Immune Responses, And Reduction In Edema Or Scar Tissue. The Antiinflammatory Actions Of Dexamethasone Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes.
Drug Interaction of Dexamethasone :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Dexamethasone :Glaucoma, Peptic Ulceration, Myopathy, Osteoporosis, Growth Retardation, Aseptic Bone Necrosis, Ocular Hypertension, Subcapsular Cataract, Pancreatic Disturbance, Cushing Like Features, Oedema, Retinal Detachment, Nausea, Vomiting, Insomnia, Nervousness, Nocturia, Increased Appetite, Obesity, Facial Rounding, Fragility Of Skin, Euphoria, Glucose Intolerance.

INTERACTIONS OF DEXAMETHASONE


How Dexamethasone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Dexamethasone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Dexamethasone

No Studies Found






Generic ( Tobramycin )



Typical use Of Tobramycin :Bacterial Infections, Biliary Tract Infections, Chronic Pulmonary Pseudomonas Aeruginosa Infection In Cystic Fibrosis Patients, Cystic Fibrosis, Endocarditis, Eye Infections, Gram +ve (some) And Gram -ve (many) Infections, Heart Failure, Iron Deficiency Anaemia, NSAID-associated Ulceration, Oliguria Due To Renal Failure, Pneumonia In Hospital Patients, Prophylaxis Of Stress Ulceration, Respiratory Tract Infections.
Mechanism of action of Tobramycin :Tobramycin Binds Irreversibly To One Of Two Aminoglycoside Binding Sites On The 30 S Ribosomal Subunit, Inhibiting Bacterial Protein Synthesis. Tobramycin May Also Destabilize Bacterial Memebrane By Binding To 16 S 16 S R-RNA.
Drug Interaction of Tobramycin :Tobramycin Is Known To Interact With Other Drugs Like Atracurium (Besylate), Calcium Gluconate, Carbenicillin (Na), Cefaclor (Monohydrate), Cefotaxime, Cephaloridine, Cisplatin, Ethacrynic Acid, Frusemide Or Furosemide, Gentamicin, Piperacillin (Na), Polymyxin B (Sulphate), Tubocurarine (Cl), Vancomycin (HCl), Vecuronium (Br). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Tobramycin :Ototoxicity, Elevation In Serum Creatinine, Neuromuscular Blockage, Skin Reactions, Maculopapular Rash, Urticaria, Local Pain, Phlebitis.

INTERACTIONS OF TOBRAMYCIN


How Tobramycin will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Tobramycin will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Tobramycin

No Studies Found