Medicine : Nizral Cream

Name:Nizral Cream
Manufacturer:Johnson & Johnson Ltd (ethnor)
Generic Use:Ketoconazole
Composition:Ketoconazole(2 % W/w X 15g)
Substitutes:nizral cream

Generic ( Ketoconazole )

Typical use Of Ketoconazole :Blastomycosis, Candidiasis, Candiduria, Chromomycosis, Chronic Mucocutaneous Candidiasis, Coccidloidomycosis, Histoplasmosis, Oesophageal Candidiasis, Orophyaryngeal Candidiasis, Paracoccidloidomycosis. Chronic Vag Candidiasis.
Mechanism of action of Ketoconazole :Ketoconazole Interacts With 14-? Demethylase, A Cytochrome P-450 Enzyme Necessary For The Conversion Of Lanosterol To Ergosterol Causes Inhibition Of Ergosterol Synthesis And Increased Fungal Cellular Permeability. Other Mechanisms May Involve The Inhibition Of Endogenous Respiration, Interaction With Membrane Phospholipids, Inhibition Of Yeast Transformation To Mycelial Forms, Inhibition Of Purine Uptake, And Impairment Of Triglyceride And/or Phospholipid Biosynthesis. Ketoconazole Can Also Inhibit The Synthesis Of Thromboxane And Sterols Such As Aldosterone, Cortisol, And Testosterone.
Drug Interaction of Ketoconazole :Ketoconazole Is Known To Interact With Other Drugs Like Abiraterone Acetate, Alcohol, Alfentanil (HCl), Aliskiren, Alprazolam, Aluminium Hydroxide And Oxide, Amphotericin B, Aprepitant, Artesunate, Astemizole, Beclomethasone (Dipropionate), Bosentan, Carbamazepine, Cimetidine (HCl), Cisapride, Corticotropin, Cyclosporin A, Dabigatran, Desonide, Didanosine, Docetaxel, Eplerenone, Erlotinib, Famotidine, Fexofenadine, Flunisolide, Indinavir (Sulphate). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Choice That May Strictly Be Required.
Side effects of Ketoconazole :Impotence, Papilloedema, Androgen Suppression, Oligospermia, Gynecomastia, Dizziness, Headache, Nausea, Vomiting, Alopecia, Diarrhea, Abdominal Pain, Urticaria, Pruritus, Itching, Thrombocytopenia, Photophobia.


How Ketoconazole will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Ketoconazole will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ketoconazole

No Studies Found