Medicine : Nistrom (1mg)

Name:Nistrom (1mg)
Manufacturer:Neiss Labs Pvt Ltd
Generic Use:Acenocoumarol
Composition:Acenocoumarol(1 Mg)
Substitutes:nistrom (1mg) , acitrom (1mg) , acitrom (1mg30mg) , acitrom 1mg1x(30tab) , acitrom 1mgtab(10s)

Generic ( Acenocoumarol )

Typical use Of Acenocoumarol :Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Embolisation.
Mechanism of action of Acenocoumarol :Acenocoumarol Inhibits Vitamin K Reductase, Resulting In Depletion Of The Reduced Form Of Vitamin K (vitamin KH2). As Vitamin K Is A Cofactor For The Carboxylation Of Glutamate Residues On The N-terminal Regions Of Vitamin K-dependent Clotting Factors, This Limits The Gamma-carboxylation And Subsequent Activation Of The Vitamin K-dependent Coagulant Proteins. The Synthesis Of Vitamin K-dependent Coagulation Factors II, VII, IX, And X And Anticoagulant Proteins C And S Is Inhibited Resulting In Decreased Prothrombin Levels And A Decrease In The Amount Of Thrombin Generated And Bound To Fibrin. This Reduces The Thrombogenicity Of Clots.
Drug Interaction of Acenocoumarol :Bismuth Carbonate And Mg Reduce Absorption. Cimetidine, Allopurinol, Diuretics And Other Oral Anticoagulants Enhance Effect. Vit K Reverses Effect. Potentiated By NSAIDs, Amiodarone, Antibacterial Agents Eg, Co-trimoxazole, Cephalosporins, Erythromycin, Quinolone Antibiotics, Chloramphenicol, Doxycycline, INH And Neomycin. Rifampicin, Barbiturates And Griseofulvin Diminish Effect.
Side effects of Acenocoumarol :Alopecia, Fever, Nausea, Vomiting, Diarrhoea, Skin Rash, Cholestatic Liver Damage, Haemorrhage.


How Acenocoumarol will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Acenocoumarol will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Acenocoumarol

No Studies Found