Medicine : Nioclean Gel(20gm)

Name:Nioclean Gel(20gm)
Type:Gel
Manufacturer:Klm Laboratories
Generic Use:Clindamycin , Nicotinamide
Composition:Clindamycin(1%) , Nicotinamide(4%)
Substitutes:nioclean gel(20gm) , nioclean gel(20gm)


Generic ( Clindamycin )



Typical use Of Clindamycin :Acne Vulgaris, Babesiosis, Bacterial Infections, Bacterial Vaginosis, Dental Infections, Endocarditis, Hidradenitis Suppurativa, Intra-abdominal Infections, Malaria, Osteomyelitis, Pelvic Infections, Peritonitis, Pulmonary Infection, Septic Arthritis, Septicaemia.
Mechanism of action of Clindamycin :Systemic/vaginal Clindamycin Inhibits Protein Synthesis Of Bacteria By Binding To The 50S Ribosomal Subunits Of The Bacteria. Specifically, It Binds Primarily To The 23s RNA Subunit. Topical Clindamycin Reduces Free Fatty Acid Concentrations On The Skin And Suppresses The Growth Of Propionibacterium Acnes (Corynebacterium Acnes) , An Anaerobe Found In Sebaceous Glands And Follicles.
Drug Interaction of Clindamycin :Clindamycin Is Known To Interact With Other Drugs Like Bamifylline, Calcium Gluconate, Distigmine (Br), Gentamicin, Lincomycin (HCl), Pancuronium (Br), Physostigmine, Rivastigmine, Rocuronium (Br), Sodium Thiosulphate.
Side effects of Clindamycin :Elevated SGPT & SGOT, Elevated Alkaline Phosphatase Concentration, Esophageal Ulceration, Pseudomembranous Colitis, Cardiac Arrest, Colonic Ulceration, Nausea, Vomiting, Abdominal Pain, Rashes, Vaginitis, Contact Dermatitis.

INTERACTIONS OF CLINDAMYCIN


How Clindamycin will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Clindamycin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Clindamycin

No Studies Found






Generic ( Nicotinamide )



Typical use Of Nicotinamide :To Treat Inflammatory Skin Disease Like Acne, Anxiety And Alzheimer’s Disease
Mechanism of action of Nicotinamide :Nicotinamide Is A Component Of Two Coenzymes, Which Bring About Tissue Respiration, Lipid, Amino Acid, Protein, And Purine Metabolism. Nicotinamide Lowers Blood Cholesterol And Triglyceride Levels By Inhibiting The Synthesis Of Very Low Density Lipoproteins.
Drug Interaction of Nicotinamide :Nicotinamide Is Known To Interact With Other Drugs Like Carbamazepine, Primidone By Reducing Its Clearance. It Also Interacts With Drugs Like Chloramphenicol, Phenytoin, Methotrexate, Penicillamine, Other Vitamins/nutritional Supplements, Antibiotics Like Ciprofloxacin, Levofloxacin And Tetracyclines. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Nicotinamide :Hepatotoxicity, Cholestasis, Portal Fibrosis, Headache, Fatigue, Urge To Vomit (nausea), Stomach Upset, Dizziness, Dry Hair, Diarrhea, Blurred Vision, Flushing And Rash.

INTERACTIONS OF NICOTINAMIDE


How Nicotinamide will impact on Pregnancy ?

There Is Sufficient Evidence To Suggest That There Is No Risk To The Fetus In The First Trimester (12 Weeks) Of Pregnancy And There Is No Evidence Of Risk In Later Trimesters. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Nicotinamide will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Nicotinamide

No Studies Found