Medicine : Nimulid Nugel(30g)

Name:Nimulid Nugel(30g)
Type:Gel
Manufacturer:Panacea Biotec Ltd
Generic Use:Menthol , Methyl Salicylate , Nimesulide
Composition:Menthol(50mg) , Methyl Salicylate(100mg) , Nimesulide(10Mg)
Substitutes:nimulid nugel(30g) , nise gel , nimulid nugel(30g) , nise gel , nimulid nugel(30g) , nise gel


Generic ( Menthol )



Typical use Of Menthol :Pharmaceutical Aid
Mechanism of action of Menthol :Menthol Primarily Activates The Cold-sensitive TRPM8 Receptors In The Skin. Menthol, After Topical Application, Causes A Feeling Of Coolness Due To Stimulation Of 'cold' Receptors By Inhibiting Ca++ Currents Of Neuronal Membranes. It May Also Yield Analgesic Properties Via Kappa-opioid Receptor Agonism.
Drug Interaction of Menthol :Menthol Is Known To Interact With Other Drugs Like Alcohol. These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Menthol :Nystagmus, Contact Dermatitis, Apnea. Menthol Produces Potentially Life-threatening Effects Which Include Coma. Overdosage Of Menthol Include Irregularities In Heart Rhythm. The Symtomatic Adverse Effects Produced By Menthol Such As Vertigo, Drowsiness, Ataxia, Abdominal Pain, Nausea And Vomiting.

INTERACTIONS OF MENTHOL


How Menthol will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Menthol will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Menthol

No Studies Found






Generic ( Methyl Salicylate )



Typical use Of Methyl Salicylate :Musculoskeletal Disorders, Peripheral Vascular Disease, Respiratory Tract Infections, Soft Tissue Disorders.
Mechanism of action of Methyl Salicylate :Methyl Salicylate Is Considered A Non-selective COX Inhibitorthat Is, It Inhibits Two Isoforms Of Cyclooxygenase, COX-1 And COX-2. The Analgesic, Antipyretic, And Anti-inflammatory Activity Of NSAIDs Appears To Be Achieved Mainly Through Inhibition Of COX-2, Whereas Inhibition Of COX-1 Would Be Responsible For Unwanted Effects On Platelet Aggregation And The Gastrointestinal Tract. Methyl Salicylate Directly And Irreversibly Inhibits The Activity Of Both Types Of Cyclo-oxygenases (COX-1 And COX-2) To Decrease The Formation Of Precursors Of Prostaglandins And Thromboxanes From Arachidonic Acid. Salicylate May Competitively Inhibit Prostaglandin Formation. Salicylate's Antirheumatic (nonsteroidal Anti-inflammatory) Actions Are A Result Of Its Analgesic And Anti-inflammatory Mechanisms.
Drug Interaction of Methyl Salicylate :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Methyl Salicylate :Irritative Skin Reactions, Skin Ulcers, Stinging Of Skin.

INTERACTIONS OF METHYL SALICYLATE


How Methyl Salicylate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Methyl Salicylate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Methyl Salicylate

No Studies Found






Generic ( Nimesulide )



Typical use Of Nimesulide :To Relieve Short-term Pain, Pain Due To Inflammation Of Joints (osteoarthritis) And Period Pains Fever.
Mechanism of action of Nimesulide :Nimesulide Is A Nonsteroidal Anti-inflammatory Drug (NSAID) That Works By Inhibiting The Synthesis Of Prostaglandins, Which Are The Chemicals Responsible For Pain, Redness And Swelling. It Also Deactivates Free Radicals That Cause Tissue Damage During Pain And Swelling.
Drug Interaction of Nimesulide :Nimesulide May Interact With Methotrexate, Cyclosporine, Digitalis Glycosides, Lithium, And Phenytoin . Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Nimesulide :Abdominal Discomfort, Abdominal Cramps, Heartburn, Urge To Vomit, Vomiting, Diarrhea, Headache,  dizziness, Drowsiness, Blood In Urine, Decrease In Urination, Kidney Failure.

INTERACTIONS OF NIMESULIDE


How Nimesulide will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Nimesulide will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Nimesulide

No Studies Found