Medicine : Nicotex (4mg)

Name:Nicotex (4mg)
Type:Tablet
Manufacturer:Cipla Ltd
Generic Use:Nicotine
Composition:Nicotine(4mg)
Substitutes:nicogum fresh mint chewing gum(4mg) , nicorette coated gum mint sugar free(4mg) , nulife goodkha chew gum(4mg) , nicotex 4sugarfreemint , nulife eucomint chew(4mg) , nicotex (4mg)


Generic ( Nicotine )



Typical use Of Nicotine : Tobacco Withdrawal.
Mechanism of action of Nicotine :Nicotine Is A Stimulant Drug That Acts As An Agonist At Nicotinic Acetylcholine Receptors. These Are Ionotropic Receptors Composed Up Of Five Homomeric Or Heteromeric Subunits. In The Brain, Nicotine Binds To Nicotinic Acetylcholine Receptors On Dopaminergic Neurons In The Cortico-limbic Pathways. This Causes The Channel To Open And Allow Conductance Of Multiple Cations Including Sodium, Calcium, And Potassium. This Leads To Depolarization, Which Activates Voltage-gated Calcium Channels And Allows More Calcium To Enter The Axon Terminal. Calcium Stimulates Vesicle Trafficking Towards The Plasma Membrane And The Release Of Dopamine Into The Synapse. Dopamine Binding To Its Receptors Is Responsible The Euphoric And Addictive Properties Of Nicotine. Nicotine Also Binds To Nicotinic Acetylcholine Receptors On The Chromaffin Cells In The Adrenal Medulla. Binding Opens The Ion Channel Allowing Influx Of Sodium, Causing Depolarization Of The Cell, Which Activates Voltage-gated Calcium Channels. Calcium Triggers The Release Of Epinephrine From Intracellular Vesicles Into The Bloodstream, Which Causes Vasoconstriction, Increased Blood Pressure, Increased Heart Rate, And Increased Blood Sugar.
Drug Interaction of Nicotine :Nicotine Is Known To Interact With Other Drugs Like Insulin, Papaverine (HCl), Propoxyphene, Theophylline. These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Nicotine :Hyperglycemia, Increased Blood Lactate, Hypoinsulinemia, Epileptic Seizures, Sweating, Respiratory Arrest, Tremor, Hyperpnea, Palpitation, Sweating, Tremor, Faintness, Paresthesias, Pallor.

INTERACTIONS OF NICOTINE


How Nicotine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Nicotine will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Nicotine

No Studies Found