Medicine : Moly Kid

Name:Moly Kid
Type:Tablet
Manufacturer:Stedman Pharmaceuticals Pvt Ltd
Generic Use:Sulphamethoxazole , Trimethoprim
Composition:Sulphamethoxazole(200 Mg) , Trimethoprim(40Mg)
Substitutes:septran paed.syp(50ml) , moly kid , septran paed.syp(50ml) , moly kid


Generic ( Sulphamethoxazole )



Typical use Of Sulphamethoxazole :Bacterial Infections, Lymphogranuloma Venereum, Respiratory Tract Infections, Urinary Tract Infection.
Mechanism of action of Sulphamethoxazole :Sulfonamides Inhibit The Enzymatic Conversion Of Pteridine And P-aminobenzoic Acid (PABA) To Dihydropteroic Acid By Competing With PABA For Binding To Dihydrofolate Synthetase, An Intermediate Of Tetrahydrofolic Acid (THF) Synthesis. THF Is Required For The Synthesis Of Purines And DTMP And Inhibition Of Its Synthesis Inhibits Bacterial Growth. Pyrimethamine And Trimethoprim Inhibit Dihydrofolate Reductase, Another Step In THF Synthesis, And Therefore Act Synergistically With The Sulfonamides.
Drug Interaction of Sulphamethoxazole :Sulfamethoxazole/trimethoprim Can Enhance The Blood-thinning Effects Of Warfarin (Coumadin), Possibly Leading To Bleeding. Sulfonamides Such As Sulfamethoxazole Can Increase The Metabolism (break-down And Elimination) Of Cyclosporine (causing Loss Of Effectiveness Of Cyclosporine), And Can Add To The Kidney Damage Caused By Cyclosporine.All Sulfonamides Can Crystallize In Urine When The Urine Is Acidic. Since Methenamine (Hiprex, Urex, Mandelamine) Causes Acidic Urine, It Should Not Be Used With Sulfonamides.Blood Levels Of Phenytoin (Dilantin) May Be Increased By Treatment With Sulfamethoxazole/trimethoprim. This May Lead To Side Effects Associated With Phenytoin (Dilantin, Dilantin-125) Such As Dizziness, And Reduced Attention. Sulfamethoxazole/trimethoprim Also May Increase Blood Levels Of Digoxin (Lanoxin) And Possibly Lead To Serious Toxic Effects. Anemia, Due To A Reduction In Folic Acid, Can Occur In Persons Receiving Sulfamethoxazole/trimethoprim In Combination With Divalproex, Valproic Acid (Depakote, Depakote ER, Depakene, Depacon, Stavzor), Methotrexate (Rheumatrex, Trexall), Pyrimethamine, Triamterene, Or Trimetrexate. Increased Blood Levels Of Potassium May Occur When Sulfamethoxazole/trimethoprim Is Combined With ACE Inhibitors.
Side effects of Sulphamethoxazole :Headache, Fatigue, Abdominal Pain, Dysuria, Malaise, Glossitis, Urinary RetentionX, Epistaxis, Urinary Retention.

INTERACTIONS OF SULPHAMETHOXAZOLE


How Sulphamethoxazole will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Sulphamethoxazole will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Sulphamethoxazole

No Studies Found






Generic ( Trimethoprim )



Typical use Of Trimethoprim :Benign Gastric And Duodenal Ulceration And Chronic Gastritis, Prophylaxis Of NSAID-induced Gastric And Duodenal Ulceration, Prophylaxis Of UTI, Respiratory Tract Infections, UTI.
Mechanism of action of Trimethoprim :Trimethoprim Binds To Dihydrofolate Reductase And Inhibits The Reduction Of Dihydrofolic Acid (DHF) To Tetrahydrofolic Acid (THF). THF Is An Essential Precursor In The Thymidine Synthesis Pathway And Interference With This Pathway Inhibits Bacterial DNA Synthesis.
Drug Interaction of Trimethoprim :Trimethoprim Is Known To Interact With Other Drugs Like Amantadine, Azathioprine, Bendrofluazide, Clozapine, Colistin (Sulphate & Sulphomethate Na), Cyclosporin A, Dapsone, Digoxin, Ganciclovir (Na), Glipizide, Hydrochlorothiazide, Lamivudine, Metformin (HCl), Methotrexate, Norgestimate, Para Aminobenzoic Acid, Phenytoin (Na), Pyrimethamine, Rifampicin, Silver Sulphadiazine, Sulfadoxine, Sulphadiazine, Sulphamethoxazole, Warfarin (Na), Zalcitabine, Zidovudine. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Trimethoprim :Vomiting, Depression, Psychosis, Mania, Facial Edema.

INTERACTIONS OF TRIMETHOPRIM


How Trimethoprim will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Trimethoprim will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Trimethoprim

No Studies Found