Medicine : Microcid Sr Caps

Name:Microcid Sr Caps
Type:Capsule
Manufacturer:Micro Labs Ltd (vision)
Generic Use:Indomethacin
Composition:Indomethacin(75 Mg)
Substitutes:indoc sr(75mg) , jdos (75mg) , indocid sr(75mg) , inocin tr(75mg) , indoflam tr(75mg) , artid sr(75mg) , inmecin r(75mg) , donica sr(75mg) , microcid sr(75mg) , indonet sr(75mg) , indocap sr(75mg) , microcid (75mg) , microcid sr caps


Generic ( Indomethacin )



Typical use Of Indomethacin :Acute Gout, Ankylosing Spondylitis, Dysmenorrhoea, Gout, Musculoskeletal Disorders, Osteoarthritis, Patency Of Ductus Arteriosus, Rheumatoid Arthritis.
Mechanism of action of Indomethacin :Indomethacin Is A Prostaglandin Synthase Inhibitor That Acts On Both Prostaglandin Synthase 1 And 2 (COX-1 And -2). Prostaglandin Synthase Catalyzes The Conversion Of Arachidonic Acid To A Number Of Prostaglandins Involved In Fever, Pain, Swelling, Inflammation, And Platelet Aggregation. Indomethacin Antagonizes COX By Binding To The Upper Portion Of The Active Site, Preventing Its Substrate, Arachidonic Acid, From Entering The Active Site. Indomethacin, Unlike Other NSAIDs, Also Inhibits Phospholipase A2, The Enzyme Responsible For Releasing Arachidonic Acid From Phospholipids. Indomethacin Is More Selective For COX-1 Than COX-2, Which Accounts For Its Increased Adverse Gastric Effects Relative To Other NSAIDs. COX-1 Is Required For Maintaining The Protective Gastric Mucosal Layer. The Analgesic, Antipyretic And Anti-inflammatory Effects Of Indomethacin Occur As A Result Of Decreased Prostaglandin Synthesis. Its Antipyretic Effects May Be Due To Action On The Hypothalamus, Resulting In An Increased Peripheral Blood Flow, Vasodilation, And Subsequent Heat Dissipation.
Drug Interaction of Indomethacin :Indomethacin Is Known To Interact With Other Drugs Like Alcohol, Aluminium Hydroxide And Oxide, Aspirin, Atenolol, Benazepril (HCl), Benorylate, Bisoprolol (Fumarate), Bumetanide, Captopril, Chlorthalidone, Choline Magnesium Trisalicylate, Cyclosporin A, Desmopressin (Acetate), Diazoxide, Diflunisal, Enalapril (Maleate), Frusemide Or Furosemide, Gentamicin, Haloperidol. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Indomethacin :Fluid Retension, Malaise, Non-specific Bloating, Overt Signs Of Heart Failure, Disorientation, Nausea, Vomiting, Convulsions, Dizziness, Lethargy, Paresthesia, Dizziness, Headache, Fatigue, Anorexia, Tinnitus, Abdominal Pain, Confusion, Somnolence.

INTERACTIONS OF INDOMETHACIN


How Indomethacin will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Indomethacin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Indomethacin

No Studies Found