Medicine : Metolactone (5mg)
|Manufacturer:||Centaur Pharmaceuticals Pvt Ltd|
|Generic Use:||Metolazone , Spironolactone|
|Composition:||Metolazone(5mg) , Spironolactone(50mg)|
|Substitutes:||metolactone (5mg) , metolactone (5mg)|
Generic ( Metolazone )
|Typical use Of Metolazone :||Congestive Heart Failure, Edema, Hepatic Disease, Hypertension, Oedema, Renal Failure.|
|Mechanism of action of Metolazone :||Metolazone Acts Primarily To Inhibit Sodium Reabsorption At The Cortical Diluting Site And To A Lesser Extent In The Proximal Convoluted Tubule. Sodium And Chloride Ions Are Excreted In Approximately Equivalent Amounts. The Increased Delivery Of Sodium To The Distal Tubular Exchange Site Results In Increased Potassium Excretion. Metolazone Does Not Inhibit Carbonic Anhydrase.|
|Drug Interaction of Metolazone :||Metolazone Is Known To Interact With Other Drugs Like Bumetanide, Captopril, Cyclosporin A, Frusemide Or Furosemide. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.|
|Side effects of Metolazone :||Hypokalemia, Hyperglycemia, Headache, Constipation, Rashes, Vertigo, Muscle Cramps, Nocturia.|
INTERACTIONS OF METOLAZONE
How Metolazone will impact on Pregnancy ?Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.
How Metolazone will impact during lactation(breastfeeding) ?Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.
Medicine & Alcohol use and effect of MetolazoneNo Studies Found
Generic ( Spironolactone )
|Typical use Of Spironolactone :||All Forms Of Epilepsy, Congestive Heart Failure, Electrolyte Disorder, For Prophylaxis In Pregnancy, Hirsutism, Hyperaldoesteronism, Hypertension, Myoclonus, Nephrotic Syndrome, Oedema, Oedema And Ascites In Cirrhosis Of The Liver, Parkinson's Disease; Drug-induced Extrapyramidal Symptoms, Primary Hyperaldosteronism, Tobacco Amblyopia And Leber's Optic Atrophy.|
|Mechanism of action of Spironolactone :||Spironolactone Acts On The Distal Renal Tubules As A Competitive Antagonist Of Aldosterone. It Increases The Excretion Of Sodium Chloride And Water While Conserving Potassium And Hydrogen Ions.|
|Drug Interaction of Spironolactone :||Sodium Excretion Effect May Be Inhibited By Aspirin. May Reduce Ulcer-healing Properties Of Carbenoxolone.|
|Side effects of Spironolactone :||Diarrhea, Drowsiness, Dizziness, Mental Confusion.|
INTERACTIONS OF SPIRONOLACTONE
How Spironolactone will impact on Pregnancy ?Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.
How Spironolactone will impact during lactation(breastfeeding) ?Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.
Medicine & Alcohol use and effect of SpironolactoneNo Studies Found