Medicine : Madoparf

Name:Madoparf
Type:Tablet
Manufacturer:Nicholas Piramal India Ltd (cognex)
Generic Use:Benserazide , Levodopa
Composition:Benserazide(50Mg) , Levodopa(200mg)
Substitutes:madoparf , madoparf


Generic ( Benserazide )


Typical use Of Benserazide : Parkinsonism.
Mechanism of action of Benserazide :Levodopa Is A Precursor To The Neurotransmitter Dopamine Which Is Administered To Increase Its Levels In The Central Nervous System. However, Most Levodopa Is Decarboxylated To Dopamine Before It Reaches The Brain, And Since Dopamine Is Unable To Cross The Bloodbrain Barrier, This Translates To Little Therapeutic Gain With Strong Peripheral Side Effects. Benserazide Inhibits This Decarboxylation, And Since It Itself Cannot Cross The Bloodbrain Barrier, This Allows Dopamine To Build Up Solely In The Brain Instead.
Drug Interaction of Benserazide :Benserazide Is Known To Interact With Other Drugs Like Levodopa. These Interactions Are Sometimes Beneficial And Sometimes May Pose Threats To Life. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Benserazide :Postural Hypotension, Psychiatric Disturbances, Fluctuating Disability, Dyskinesias, Hypotension, Cardiac Arrhythmias, Nausea, Vomiting, Elevated Alkaline Phosphatase.

INTERACTIONS OF BENSERAZIDE

How Benserazide will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Benserazide will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Benserazide

No Studies Found





Generic ( Levodopa )


Typical use Of Levodopa :Idiopathic, Post-encephalitis And Arteriosclerotic Parkinsonism.
Mechanism of action of Levodopa :Striatal Dopaminergic Neurotransmission May Be Enhanced By Exogenous Supplementation Of Dopamine Through Administration Of Dopamine's Precursor, Levodopa. A Small Percentage Of Each Levodopa Dose Crosses The Blood-brain Barrier And Is Decarboxylated To Dopamine. This Newly Formed Dopamine Then Is Available To Stimulate Dopaminergic Receptors, Thus Compensating For The Depleted Supply Of Endogenous Dopamine.
Drug Interaction of Levodopa :Levodopa Is Known To Interact With Other Drugs Like Adrenaline, Alprazolam, Amitriptyline (HCl), Benserazide (HCl), Biperiden (HCl), Bupropion (HCl), Cabergoline, Clonidine (HCl), Dacarbazine, Diazepam, Diazoxide, Droperidol, Drotaverine, Ephedrine, Flupenthixol (HCl And Decanoate), Furazolidone, Gonadorelin (HCl), Guanethidine, Haloperidol, Halothane, Imipramine (HCl), Iron Salts, Isocarboxazid, Isoproterenol, Lisuride, Methyldopa, Metoclopramide (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Levodopa :Hallucinations, Delirium, Dyskinesias, Mental Disturbances, Cardiac Irregularities, Bradyphrenia, Nausea, Vomiting, Anorexia, Diarrhea, Palpitation, Constipation, Abdominal Pain, GI Upset, Elevated Alkaline Phosphatase.

INTERACTIONS OF LEVODOPA

How Levodopa will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Levodopa will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Levodopa

No Studies Found