Medicine : Lobate Gm Neo(20gm)

Name:Lobate Gm Neo(20gm)
Type:Cream
Manufacturer:Nicholas Piramal India Ltd
Generic Use:Clobetasole Propionate , Neomycin Sulphate , Miconazole
Composition:Clobetasole Propionate(0.05%w /w) , Neomycin Sulphate(0.5%w /w) , Miconazole(2%w /w)
Substitutes:lobate gm neo(20gm) , lobate gm neo(20gm) , lobate gm neo(20gm)


Generic ( Clobetasole Propionate )



Typical use Of Clobetasole Propionate :Skin Infection
Mechanism of action of Clobetasole Propionate :The Precise Mechanism Of The Antiinflammatory Activity Of Topical Steroids In The Treatment Of Steroid-responsive Dermatoses, In General, Is Uncertain. However, Corticosteroids Are Thought To Act By The Induction Of Phospholipase A2 Inhibitory Proteins, Collectively Called Lipocortins. It Is Postulated That These Proteins Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes By Inhibiting The Release Of Their Common Precursor Arachidonic Acid. Arachidonic Acid Is Released From Membrane Phospholipids By Phospholipase A2. Initially, However, Clobetasol, Like Other Corticosteroids, Bind To The Glucocorticoid Receptor, Which Complexes, Enteres The Cell Nucleus And Modifies Genetic Transcription (transrepression/transactivation).
Drug Interaction of Clobetasole Propionate :If Overdose Is Suspected, Contact Your Physician.
Side effects of Clobetasole Propionate :Headache, Fatigue, Nausea, Constipation, Dry Mouth, Sedation, Skin Rash, Gastralgia.

INTERACTIONS OF CLOBETASOLE PROPIONATE


How Clobetasole Propionate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Clobetasole Propionate will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Clobetasole Propionate

No Studies Found






Generic ( Neomycin Sulphate )



Typical use Of Neomycin Sulphate :Decontamination Of Digestive Tract, Hepatic Coma, Hepatic Encephalopathy, Pre-operative Bowel Sterilization, Sepsis, Skin Infections
Mechanism of action of Neomycin Sulphate :Neomycin Irreversibly Bind To Specific 30S-subunit Proteins And 16S RRNA. Specifically Neomycin Binds To Four Nucleotides Of 16S RRNA And A Single Amino Acid Of Protein S12. This Interferes With Decoding Site In The Vicinity Of Nucleotide 1400 In 16S RRNA Of 30S Subunit. This Region Interacts With The Wobble Base In The Anticodon Of TRNA. This Leads To Interference With The Initiation Complex, Misreading Of MRNA So Incorrect Amino Acids Are Inserted Into The Polypeptide Leading To Nonfunctional Or Toxic Peptides And The Breakup Of Polysomes Into Nonfunctional Monosomes.
Drug Interaction of Neomycin Sulphate :Neomycin Is Known To Interact With Other Drugs Like Acarbose, Atracurium (Besylate), Cyanocobalamin, Digoxin, Doxacurium, Fluorouracil, Gentamicin, Gestodene, Hydroxocobalamin, Mecobalamin, Methotrexate, Pancuronium (Br). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Neomycin Sulphate :Urticaria, Angioneurotic Edema, Ototoxicity, Blood Dyscrasias, Anaphylactic Shock, Renal Failure, Vertigo, Headache, Diarrhea, Tinnitus, Pruritus, Lethargy, Skin Rash, Contact Dermatitis.

INTERACTIONS OF NEOMYCIN SULPHATE


How Neomycin Sulphate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Neomycin Sulphate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Neomycin Sulphate

No Studies Found






Generic ( Miconazole )



Typical use Of Miconazole :Vulvo-vaginal Candidiasis, Balanitis.Tinea Vapitis, T Corporis, T Manuum, T Pedis (atheletes Foot), T Barbae, T Cruris, T Unguium Or Onychomycosis, Pityriasis Versicolor.Candidiasis Of Skin And Nails.
Mechanism of action of Miconazole :Miconazole Interacts With 14-? Demethylase, A Cytochrome P-450 Enzyme Necessary To Convert Lanosterol To Ergosterol, Causes Inhibition Of Ergosterol Synthesis Results In Increased Cellular Permeability Causing Leakage Of Cellular Contents. Miconazole May Also Inhibit Endogenous Respiration, Interact With Membrane Phospholipids, Inhibit The Transformation Of Yeasts To Mycelial Forms, Inhibit Purine Uptake, And Impair Triglyceride And/or Phospholipid Biosynthesis.
Drug Interaction of Miconazole :Miconazole (Nitrate) Is Known To Interact With Other Drugs Like Alprazolam, Amphotericin B,astemizole, Carbamazepine, Cisapride, Fosphenytoin, Phenytoin (Na). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Miconazole :Cardiac Arrhythmias, Phlebitis, Pruritis, Arachnoiditis, Cardiac Arrest, Anaphylaxis, Drowsiness, Anorexia, Rashes, GI Upset, Flushing, Nausea And Vomiting

INTERACTIONS OF MICONAZOLE


How Miconazole will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Miconazole will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Miconazole

No Studies Found