Generic ( Lithium )


Typical use Of Lithium :Acute Hypomania, Mania, Recurrent Mania. Depression. Prophylaxis Of MDP. Recurrent Neuropsychiatric Illness. ADH Secretion Syndrome.
Mechanism of action of Lithium :Li+ Typically Produces No Obvious Psychotropic Effects (such As Euphoria) In Normal Individuals At Therapeutic Concentrations. Li+ Possibly Produces Its Effects By Interacting With The Transport Of Monovalent Or Divalent Cations In Neurons. However, Because It Is A Poor Substrate At The Sodium Pump, It Cannot Maintain A Membrane Potential And Only Sustains A Small Gradient Across Biological Membranes. Li+ Is Similar Enough To Na+ That Under Experimental Conditions, It Can Replace Na+ For Production Of A Single Action Potential In Neurons.Lithium Deactivates The GSK3? Enzyme. This Enzyme Normally Phosphorylates The Rev-Erb? Transcription Factor Protein Stabilizing It Against Degradation. Rev-Erb? In Turn Represses BMAL1, A Component Of The Circadian Clock. Hence, Lithium By Inhibiting GSK3? Causes The Degradation Of Rev-Erb? And Increases The Expression Of BMAL Which Dampens The Circadian Clock. Through This Mechanism, Lithium Is Able To Block The Resetting Of The "master Clock" Inside The Brain; As A Result, The Body's Natural Cycle Is Disrupted. When The Cycle Is Disrupted, The Routine Schedules Of Many Functions (metabolism, Sleep, Body Temperature) Are Disturbed. Lithium May Thus Restore Normal Brain Function After It Is Disrupted In Some People.
Drug Interaction of Lithium :Lithium Is Known To Interact With Other Drugs Like Alcohol, Amiloride (HCl), Azapropazone, Baclofen, Bendrofluazide, Bumetanide, Bupropion (HCl), Captopril, Carbamazepine, Celecoxib, Chlorothiazide, Chlorpromazine (HCl), Chlortetracycline (HCl), Chlorthalidone, Cilazapril, Clopamide, Clozapine, Cyclopenthiazide, Demeclocycline (HCl), Desipramine (HCl), Desmopressin (Acetate), Dexamphetamine (Sulphate), Dexibuprofen, Diazepam, Diclofenac (Na), Diltiazem (HCl), Distigmine (Br), Doxacurium, Doxepin (HCl).
Side effects of Lithium :Convulsions, Cardiac Arrhythmias, Dehydration, Sinus Bradycardia, Bradycardia, Cardiac Arrhythmias, Polyuria, Glycosuria, Tinnitus, Permanent Disability, Drowsiness, Ataxia, Anorexia, Diarrhea, Confusion, Weight Gain, Polyuria, Muscle Weakness, Tremor, Nausea And Vomiting, ECG Changes, Psoriasis.


INTERACTIONS OF LITHIUM


How Lithium will impact on Pregnancy ?

Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown Risk To Fetus. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Lithium will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Lithium

No Studies Found