Generic ( Levosimendan )


Typical use Of Levosimendan :For Short Term Treatment Of Acutely Decompensated Severe Chronic Heart Failure.
Mechanism of action of Levosimendan :Levosimendan Increases The Sensitivity Of The Heart To Calcium, Thus Increasing Cardiac Contractility Without A Rise In Intracellular Calcium. Levosimendan Exerts Its Positive Inotropic Effect By Increasing Calcium Sensitivity Of Myocytes By Binding To Cardiac Troponin C In A Calcium-dependent Manner. It Also Has A Vasodilatory Effect, By Opening Adenosine Triphosphate (ATP)-sensitive Potassium Channels In Vascular Smooth Muscle To Cause Smooth Muscle Relaxation. The Combined Inotropic And Vasodilatory Actions Result In An Increased Force Of Contraction, Decreased Preload And Decreased Afterload. Moreover, By Opening Also The Mitochondrial (ATP)-sensitive Potassium Channels In Cardiomyocytes, The Drug Exerts A Cardioprotective Effect.
Drug Interaction of Levosimendan :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Levosimendan :Headache, Hypotension, Arrhythmias (atrial Fibrillation, Extrasystoles, Atrial Tachycardia, Ventricular Tachycardia), Myocardial Ischaemia, Hypokalaemia, Nausea.


INTERACTIONS OF LEVOSIMENDAN


How Levosimendan will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Levosimendan will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Levosimendan

No Studies Found