Medicine : Larinate Kit

Name:Larinate Kit
Type:Strip
Manufacturer:Ipca Laboratories Ltd
Generic Use:Artesunate , Pyrimethamine , Sulphadoxine
Composition:Artesunate(200 Mg) , Pyrimethamine(25 Mg) , Sulphadoxine (1 Tabs)(500 Mg)
Substitutes:larinate (200kit) , larinate kit , larinate (200kit) , larinate kit , larinate (200kit) , larinate kit


Generic ( Artesunate )



Typical use Of Artesunate :Severe Malaria Including Cerebral Malaria And As A Second Line Treatment In Chloroquine Resistant Falciparum Malaria.
Mechanism of action of Artesunate :Artesunate Is A Potent And Rapidly-acting Blood Schizontocide Derived From The Leaves Of The Chinese Herb, Armesia Annua. The Exact Mode Of Action Is Not Clear But Clinical Studies Have Confirmed The Effectiveness Of Artesunate In P. Vivax And Falciparum Malaria.
Drug Interaction of Artesunate :Antimalarial Potentiating Action Seen With Mefloquine, Primaquine And Tetracycline. Additive Effect With Chloroquine. Antagonistic Effect With Pyrimethamine And Sulphonamides.
Side effects of Artesunate :Transient And Reversible Reticulocytopaenia, Drug Fever, Rash, Bradycardia, Transient 1st-degree Heart Block And Reversible Elevation Of Serum Transaminases.

INTERACTIONS OF ARTESUNATE


How Artesunate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Artesunate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Artesunate

No Studies Found






Generic ( Pyrimethamine )



Typical use Of Pyrimethamine :Malaria, Malaria Prophylaxis, Malaria Treatment, Protozoa Infection, Toxoplasmosis.
Mechanism of action of Pyrimethamine :Pyrimethamine Inhibits The Dihydrofolate Reductase Of Plasmodia And Thereby Blocks The Biosynthesis Of Purines And Pyrimidines, Which Are Essential For DNA Synthesis And Cell Multiplication. This Leads To Failure Of Nuclear Division At The Time Of Schizont Formation In Erythrocytes And Liver.
Drug Interaction of Pyrimethamine :None Mentioned.
Side effects of Pyrimethamine :Agranulocytosis, Disseminated Intravascular Coagulation.

INTERACTIONS OF PYRIMETHAMINE


How Pyrimethamine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Pyrimethamine will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Pyrimethamine

No Studies Found






Generic ( Sulphadoxine )



Typical use Of Sulphadoxine :Information Not Available.
Mechanism of action of Sulphadoxine :Information Not Available.
Drug Interaction of Sulphadoxine :Information Not Available.
Side effects of Sulphadoxine :Information Not Available.

INTERACTIONS OF SULPHADOXINE


How Sulphadoxine will impact on Pregnancy ?

Information Not Available.

How Sulphadoxine will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Sulphadoxine

Information Not Available.