Generic ( Lafutidine )


Typical use Of Lafutidine :Used For Treatment Of Ulcer, Suppresses Gastric Acid Secretion.
Mechanism of action of Lafutidine :Acid Suppressive Action: Lafutidine Is Absorbed In The Small Intestine, Reaches Gastric Cells Via The Systemic Circulation, And Then Directly And Rapidly Binds To Gastric Cell Histamine H2 Receptors, Thereby Inhibiting The Stimulation Of CAMP And A Resultant Decrease In Acid Production (antisecretory Action). It Causes A Sustained Increase In Intracellular Ca2+ Ion Concentration In Endothelial Cells Resulting In The Release Of Calcitonin Gene Related Peptide (CGRP), Which Causes Acid Suppression By Decreasing The Vagal Tone.Gastroprotective Action: Lafutidine Induced CGRP Release Stimulates Nitric Oxide (NO) Production In Endothelial Cells, Where NO Participates In The Regulation Of Gastric Mucosal Blood Flow Through Vasodilation In The Gastric Microvasculature And Increases Mucin Biosynthesis Resulting In Gastroprotection. Lafutidine Inhibits Secretion Of Interleukin-8, Which In Turn Inhibits Sequestration Of Neutrophils At The Site Of Inflammation, Thereby Preventing Mucosal Inflammation. It Also Inhibits Neutrophil Activation Which Reduces Damage Caused By Free Radicals, Thereby Reducing Inflammation.
Drug Interaction of Lafutidine :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Lafutidine :Constipation, Hyperuricaemia, Increase In LFT And Total Bilirubin, Gynaecomastia, Anorexia, Hallucinations, Increase In Liver Enzymes, Increased Level Of Blood Urea, Loss Of Appetite.


INTERACTIONS OF LAFUTIDINE


How Lafutidine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Lafutidine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Lafutidine

No Studies Found