Generic ( Labetalol )

Typical use Of Labetalol :Angina, Constipation And Bowel Evacuation, Drying Secretions, Hypertension, Hypertension Following Myocardial Infarction, Hypertensive Emergencies, Hypotension Induction With Anesthesia.
Mechanism of action of Labetalol :Labetalol Combines Both Selective, Competitive, Alpha-1-adrenergic Blocking And Nonselective, Competitive, Beta-adrenergic Blocking Activity In A Single Substance. Labetalol Competitively Block Adrenergic Stimulation Of ?-receptors Within The Myocardium (?1-receptors) And Within Bronchial And Vascular Smooth Muscle (?2-receptors), And ?1-receptors Within Vascular Smooth Muscle. This Causes A Decrease In Systemic Arterial Blood Pressure And Systemic Vascular Resistance Without A Substantial Reduction In Resting Heart Rate, Cardiac Output, Or Stroke Volume, Apparently Because Of Its Combined ?- And ?-adrenergic Blocking Activity.
Drug Interaction of Labetalol :Labetalol Is Known To Interact With Other Drugs Like Alprazolam, Atropine (Sulphate), Cimetidine (HCl), Diltiazem (HCl), Halothane, Imipramine (HCl). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Labetalol :Bronchospasm, Hepatic Necrosis, Systemic Lupus Erythematosus, Myopathy, Urinary Retention, Dizziness, Heart Failure, Fatigue, Headache, Nausea, Vomiting, Diarrhea, Nasal Stiffiness, Weight Gain, Nightmares, Chest Pain, Shortening Of Breath.


How Labetalol will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Labetalol will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Labetalol

No Studies Found