Medicine : Knoz

Name:Knoz
Type:Tablet
Manufacturer:Laxian Incorporation
Generic Use:Itraconazole
Composition:Itraconazole(100mg)
Substitutes:icoz (100mg) , fulcover (100mg) , afo (100mg) , citroz (100mg) , fungitrace (100mg) , itrole (100mg) , biospore (100mg) , itra (100mg) , itaspor (100mg) , canditral (100mg) , candistat (100mg) , sporanox (100mg) , itrafaze (100mg) , candiforce (100mg) , canditral , knoz , onitraz (100mg)


Generic ( Itraconazole )



Typical use Of Itraconazole : Feeling Of Gastric Fullness, Epigastric Pain, Anorexia, Heartburn, Regurgitation, Bloating Nausea And Vomiting.
Mechanism of action of Itraconazole :Itraconazole Interacts With 14-? Demethylase, A Cytochrome P-450 Enzyme Necessary To Convert Lanosterol To Ergosterol. As Ergosterol Is An Essential Component Of The Fungal Cell Membrane, Inhibition Of Its Synthesis Results In Increased Cellular Permeability Causing Leakage Of Cellular Contents. Itraconazole May Also Inhibit Endogenous Respiration, Interact With Membrane Phospholipids, Inhibit The Transformation Of Yeasts To Mycelial Forms, Inhibit Purine Uptake, And Impair Triglyceride And/or Phospholipid Biosynthesis.
Drug Interaction of Itraconazole :Itraconazole Is Known To Interact With Other Drugs Like Aliskiren, Alprazolam, Artesunate, Astemizole, Bosentan, Buspirone (HCl), Busulphan, Calcium Carbonate, Carbamazepine, Cisapride, Cyclosporin A, Digoxin, Erlotinib, Felodipine, Fexofenadine, Indinavir (Sulphate), Lovastatin, Midazolam, Mizolastine.
Side effects of Itraconazole :Hepatitis, Hypertension, Dizziness, Headache, Fatigue, Nausea, Vomiting, Diarrhea, Abdominal Pain, Pruritus, Hallucination, Somnolence, Hair Loss, Edema.

INTERACTIONS OF ITRACONAZOLE


How Itraconazole will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Itraconazole will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Itraconazole

No Studies Found