Generic ( Ivabradine )


Typical use Of Ivabradine :Treatment Of Coronary Artery Disease, Treatment Of Chronic Heart Failure.
Mechanism of action of Ivabradine :Ivabradine Acts On The If (f Is For "funny") Ion Current, Which Is Highly Expressed In The Sinoatrial Node. If Is A Mixed Na+K+ Inward Current Activated By Hyperpolarization And Modulated By The Autonomic Nervous System. It Is One Of The Most Important Ionic Currents For Regulating Pacemaker Activity In The Sinoatrial (SA) Node. Ivabradine Selectively Inhibits The Pacemaker If Current In A Dose-dependent Manner. Blocking This Channel Reduces Cardiac Pacemaker Activity, Slowing The Heart Rate And Allowing More Time For Blood To Flow To The Myocardium.
Drug Interaction of Ivabradine :Ivabradine Is Known To Interact With Other Drugs Like Ketoconazole, Macrolide Antibiotics, Cyclosporin, Gestodene, Anti-retroviral Drugs, Verapamil. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Ivabradine :Blurred Vision, Bradycardia, Ventricular Extrasystoles, Atrioventricular First Degree Block, Headache, Dizziness, Myocardial Infarction, Ventricular Tachycardia, Vertigo, Nausea, Constipation, Diarrhoea, Asthenia, Fatigue, Elevated Creatinine In Blood, ECG Prolonged QT Interval, Hyperuricaemia, Muscle Cramps, Syncope, Dyspnoea, Hypotension, Angioedema, Rash.


INTERACTIONS OF IVABRADINE


How Ivabradine will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Ivabradine will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ivabradine

No Studies Found