Generic ( Isosorbide Dinitrate )

Typical use Of Isosorbide Dinitrate :For The Prevention Of Angina Pectoris Due To Coronary Artery Disease.
Mechanism of action of Isosorbide Dinitrate :Isosorbide Dinitrate Is Converted To Nitric Oxide (NO), An Active Intermediate Compound Which Activates The Enzyme Guanylate Cyclase (atrial Natriuretic Peptide Receptor A). This Stimulates The Synthesis Of Cyclic Guanosine 3',5'-monophosphate (cGMP) Which Then Activates A Series Of Protein Kinase-dependent Phosphorylations In The Smooth Muscle Cells, Eventually Resulting In The Dephosphorylation Of The Myosin Light Chain Of The Smooth Muscle Fiber. The Subsequent Release Of Calcium Ions Results In The Relaxation Of The Smooth Muscle Cells And Vasodilation.
Drug Interaction of Isosorbide Dinitrate :Isosorbide Dinitrate Is Known To Interact With Other Drugs Like Avanafil, Dihydroergotamine, Dihydroergotoxine, Ergonovine, Methylergonovine, Sildenafil, Telithromycin, Udenafil, Voriconazole. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Isosorbide Dinitrate :Tachycardia, Flushing, Headache, Dizziness, Palpitation, Syncope, Confusion, Nausea, Vomiting, Abdominal Pain, Apprehension, Restlessness, Weakness.


How Isosorbide Dinitrate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Isosorbide Dinitrate will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Isosorbide Dinitrate

No Studies Found