Medicine : Insuman Comb 25/(75inj)

Name:Insuman Comb 25/(75inj)
Type:Injection
Manufacturer:Sanofi India Ltd (aventis)
Generic Use:Insulin Lispro Protamine , Insulin Lispro
Composition:Insulin Lispro Protamine(75%) , Insulin Lispro(25%)
Substitutes:humalog mix(25mg) , insuman comb(25) , insuman comb 25/(75inj) , humalog mix(25mg) , insuman comb(25) , insuman comb 25/(75inj)


Generic ( Insulin Lispro Protamine )



Typical use Of Insulin Lispro Protamine :Diabetes Mellitus.
Mechanism of action of Insulin Lispro Protamine :Insulin Lispro Protamine Binds To The Insulin Receptor (IR), A Heterotetrameric Protein Consisting Of Two Extracellular Alpha Units And Two Transmembrane Beta Units. The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC).
Drug Interaction of Insulin Lispro Protamine :Insulin Lispro Protamine Is Known To Interact With Other Drugs Like Corticosteroids, Isoniazid, Certain Lipid-lowering Drugs, Oestrogens, Oral Contraceptives, Phenothiazines, Sulfa Antibiotics, Certain Antidepressants (MAOIs), ACE Inhibitors, Angiotensin II Receptor Blocking Agents, ?-adrenergic Blockers, Octreotide And Alcohol.
Side effects of Insulin Lispro Protamine :Redness, Swelling, Itching At The Site Of Inj, Lipodystrophy, Pruritus And Rash.

INTERACTIONS OF INSULIN LISPRO PROTAMINE


How Insulin Lispro Protamine will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Insulin Lispro Protamine will impact during lactation(breastfeeding) ?

Safer: Drug Has Been Studied In Few Breastfeeding Women And The Evidence Shows That There Is No Increase In Side Effects In The Infants, Or The Possibility Of Harm To The Breastfed Infants Is Expected To Be Rare. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Insulin Lispro Protamine

No Studies Found






Generic ( Insulin Lispro )



Typical use Of Insulin Lispro :Insulin Dependent Diabetes Mellitus.
Mechanism of action of Insulin Lispro :Insulin Lispro Binds To The Insulin Receptor (IR), A Heterotetrameric Protein Consisting Of Two Extracellular Alpha Units And Two Transmembrane Beta Units. The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC). Hexamers Of Insulin Lispro Are Produced In The Presence Of Zinc And M-cresol. These Weakly Associated Hexamers Quickly Dissociate Upon Subcutaneous Injection And Are Absorbed As Monomers Through Vascular Endothelial Cells. These Properties Give Insulin Lispro Its Fast-acting Properties.
Drug Interaction of Insulin Lispro :Insulin Lispro Is Known To Interact With Other Drugs Like Alcohol, Amitriptyline (HCl), Aspirin, Chlordiazepoxide (HCl), Chlorpromazine (HCl), Diazoxide, Diltiazem (HCl), Disopyramide, Fenfluramine (HCl), Guanethidine, Lithium, Mebendazole, Nifedipine, Octreotide (Acetate). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Insulin Lispro :Hypoglycemia, Lipoatrophy, Allergic Reactions, Swelling Of Feet.

INTERACTIONS OF INSULIN LISPRO


How Insulin Lispro will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Insulin Lispro will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Insulin Lispro

No Studies Found