Medicine : Humalog Mix(25disposable)

Name:Humalog Mix(25disposable)
Type:Injection
Manufacturer:Eli Lilly And Company India Pvt Ltd
Generic Use:Insulin Lispro
Composition:Insulin Lispro(100 IU)
Substitutes:novorapid flexpen(10ml) , novorapid penfill(100iu) , humalog (100iu) , insuman rapid cartridge , humalog mix(25disposable)


Generic ( Insulin Lispro )


Typical use Of Insulin Lispro :Insulin Dependent Diabetes Mellitus.
Mechanism of action of Insulin Lispro :Insulin Lispro Binds To The Insulin Receptor (IR), A Heterotetrameric Protein Consisting Of Two Extracellular Alpha Units And Two Transmembrane Beta Units. The Binding Of Insulin To The Alpha Subunit Of IR Stimulates The Tyrosine Kinase Activity Intrinsic To The Beta Subunit Of The Receptor. The Bound Receptor Autophosphorylates And Phosphorylates Numerous Intracellular Substrates Such As Insulin Receptor Substrates (IRS) Proteins, Cbl, APS, Shc And Gab 1. Activation Of These Proteins Leads To The Activation Of Downstream Signaling Molecules Including PI3 Kinase And Akt. Akt Regulates The Activity Of Glucose Transporter 4 (GLUT4) And Protein Kinase C (PKC). Hexamers Of Insulin Lispro Are Produced In The Presence Of Zinc And M-cresol. These Weakly Associated Hexamers Quickly Dissociate Upon Subcutaneous Injection And Are Absorbed As Monomers Through Vascular Endothelial Cells. These Properties Give Insulin Lispro Its Fast-acting Properties.
Drug Interaction of Insulin Lispro :Insulin Lispro Is Known To Interact With Other Drugs Like Alcohol, Amitriptyline (HCl), Aspirin, Chlordiazepoxide (HCl), Chlorpromazine (HCl), Diazoxide, Diltiazem (HCl), Disopyramide, Fenfluramine (HCl), Guanethidine, Lithium, Mebendazole, Nifedipine, Octreotide (Acetate). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Insulin Lispro :Hypoglycemia, Lipoatrophy, Allergic Reactions, Swelling Of Feet.

INTERACTIONS OF INSULIN LISPRO

How Insulin Lispro will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Insulin Lispro will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Insulin Lispro

No Studies Found