Generic ( Glyceryl Trinitrate )


Typical use Of Glyceryl Trinitrate :Angina Pectoris, Cardiac Failure, Cardiopulmonary Oedema, Long-term Treatment Of Healed Reflux Oesophagitis, Moderate To Severe Reflux Oesophagitis, Myocardial Infarction, Oesophageal Spasm, Oesophageal Spasm, Postoperative Hypertension, Prinzmetal's Angina.
Mechanism of action of Glyceryl Trinitrate :Nitroglycerin Is Converted To Nitric Oxide (NO), An Active Intermediate Compound Which Activates The Enzyme Guanylate Cyclase. This Stimulates The Synthesis Of Cyclic Guanosine 3',5'-monophosphate (cGMP) Which Then Activates A Series Of Protein Kinase-dependent Phosphorylations In The Smooth Muscle Cells, Eventually Resulting In The Dephosphorylation Of The Myosin Light Chain Of The Smooth Muscle Fiber. The Subsequent Release Of Calcium Ions Results In The Relaxation Of The Smooth Muscle Cells And Vasodilation.
Drug Interaction of Glyceryl Trinitrate :Angina Pectoris, Cardiac Failure, Cardiopulmonary Oedema, Long-term Treatment Of Healed Reflux Oesophagitis, Moderate To Severe Reflux Oesophagitis, Myocardial Infarction, Oesophageal Spasm, Oesophageal Spasm, Postoperative Hypertension, Prinzmetal's Angina.
Side effects of Glyceryl Trinitrate :Tachycardia, Bradycardia, Collapse, Metabolic Acidosis, Cardiovascular Collapse, Syncope, Neurologic Deficit, Methemoglobinemia, Weakness, Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Abdominal Pain, Vertigo, Urinary Incontinence, Syncope, Fecal Incontinence.


INTERACTIONS OF GLYCERYL TRINITRATE


How Glyceryl Trinitrate will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Glyceryl Trinitrate will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Glyceryl Trinitrate

No Studies Found