Generic ( Gentamicin )


Typical use Of Gentamicin :Severe Infections Caused By Susceptible Gm Negative Organisms Eg - Billary Tract Infections, Brucellosis, Cat Scratch Disease, Cystic Fibrosis, Endocarditis, Endometritis, Gastroenteritis, Granuloma Inguinale, Listeriosis, Meningitis, Otitis Externa, Pelvic Inflammatory Disease, Peritonitis, Plaque, Pneumonia, Septicaemia, Skin Infections, UTI.
Mechanism of action of Gentamicin :Aminoglycosides Like Gentamicin "irreversibly" Bind To Specific 30S-subunit Proteins And 16S RRNA. Specifically Gentamicin Binds To Four Nucleotides Of 16S RRNA And A Single Amino Acid Of Protein S12. This Interferes With Decoding Site In The Vicinity Of Nucleotide 1400 In 16S RRNA Of 30S Subunit. This Region Interacts With The Wobble Base In The Anticodon Of TRNA. This Leads To Interference With The Initiation Complex, Misreading Of MRNA So Incorrect Amino Acids Are Inserted Into The Polypeptide Leading To Nonfunctional Or Toxic Peptides And The Breakup Of Polysomes Into Nonfunctional Monosomes.
Drug Interaction of Gentamicin :Gentamicin Is Known To Interact With Other Drugs Like Atracurium (Besylate), Capreomycin, Cefaclor (Monohydrate), Cefotaxime, Cisplatin, Clindamycin, Cyclosporin A, Cytarabine (HCl), Ethacrynic Acid, Ethacrynic Acid, Floxacillin (Na), Foscarnet (Na), Frusemide Or Furosemide, Hydrocortisone, Indomethacin.
Side effects of Gentamicin :Encephalopathy, Convulsions, Hallucinations, Nephrotoxicity, Neuromuscular Blockage, Nephrotoxicity, Ototoxicity, Dizziness, Vertigo, Fever, Ototoxicity, Skin Rashes, Exfoliative Dermatitis, Eosinophilia, Purpura, Angioedema, Pyuria, Proteinuria, Azotemia.


INTERACTIONS OF GENTAMICIN


How Gentamicin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Gentamicin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Gentamicin

No Studies Found