Medicine : Gentacort D Eye Drop(10ml)

Name:Gentacort D Eye Drop(10ml)
Type:Drop
Manufacturer:Laborate Pharmaceuticals India Ltd
Generic Use:Gentamicin , Dexamethasone
Composition:Gentamicin(0.3 % W/v) , Dexamethasone(0.01% W/v)
Substitutes:gentacort d eye drop(10ml) , gentacort d eye drop(10ml)


Generic ( Gentamicin )



Typical use Of Gentamicin :Severe Infections Caused By Susceptible Gm Negative Organisms Eg - Billary Tract Infections, Brucellosis, Cat Scratch Disease, Cystic Fibrosis, Endocarditis, Endometritis, Gastroenteritis, Granuloma Inguinale, Listeriosis, Meningitis, Otitis Externa, Pelvic Inflammatory Disease, Peritonitis, Plaque, Pneumonia, Septicaemia, Skin Infections, UTI.
Mechanism of action of Gentamicin :Aminoglycosides Like Gentamicin "irreversibly" Bind To Specific 30S-subunit Proteins And 16S RRNA. Specifically Gentamicin Binds To Four Nucleotides Of 16S RRNA And A Single Amino Acid Of Protein S12. This Interferes With Decoding Site In The Vicinity Of Nucleotide 1400 In 16S RRNA Of 30S Subunit. This Region Interacts With The Wobble Base In The Anticodon Of TRNA. This Leads To Interference With The Initiation Complex, Misreading Of MRNA So Incorrect Amino Acids Are Inserted Into The Polypeptide Leading To Nonfunctional Or Toxic Peptides And The Breakup Of Polysomes Into Nonfunctional Monosomes.
Drug Interaction of Gentamicin :Gentamicin Is Known To Interact With Other Drugs Like Atracurium (Besylate), Capreomycin, Cefaclor (Monohydrate), Cefotaxime, Cisplatin, Clindamycin, Cyclosporin A, Cytarabine (HCl), Ethacrynic Acid, Ethacrynic Acid, Floxacillin (Na), Foscarnet (Na), Frusemide Or Furosemide, Hydrocortisone, Indomethacin.
Side effects of Gentamicin :Encephalopathy, Convulsions, Hallucinations, Nephrotoxicity, Neuromuscular Blockage, Nephrotoxicity, Ototoxicity, Dizziness, Vertigo, Fever, Ototoxicity, Skin Rashes, Exfoliative Dermatitis, Eosinophilia, Purpura, Angioedema, Pyuria, Proteinuria, Azotemia.

INTERACTIONS OF GENTAMICIN


How Gentamicin will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Gentamicin will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Gentamicin

No Studies Found






Generic ( Dexamethasone )



Typical use Of Dexamethasone :Anorexia In Palliative Care, Congenital Adrenal Hyperplasia, Dyspnoea, Dyspnoea In Palliative Care, Headache Due To Raised Intracranial Pressure In Palliative Care, Nausea And Vomiting (chemotherapy Induced), Pain Due To Nerve Compression In Palliative Care, Raised Intracranial Pressure, Respiratory Distress Syndrome, Shock, Suppression Of Inflammatory And Allergic Disorders.
Mechanism of action of Dexamethasone :Dexamethasone Is A Glucocorticoid Agonist. Unbound Dexamethasone Crosses Cell Membranes And Binds With High Affinity To Specific Cytoplasmic Glucocorticoid Receptors. This Complex Binds To DNA Elements (glucocorticoid Response Elements) Which Results In A Modification Of Transcription And, Hence, Protein Synthesis In Order To Achieve Inhibition Of Leukocyte Infiltration At The Site Of Inflammation, Interference In The Function Of Mediators Of Inflammatory Response, Suppression Of Humoral Immune Responses, And Reduction In Edema Or Scar Tissue. The Antiinflammatory Actions Of Dexamethasone Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes.
Drug Interaction of Dexamethasone :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Dexamethasone :Glaucoma, Peptic Ulceration, Myopathy, Osteoporosis, Growth Retardation, Aseptic Bone Necrosis, Ocular Hypertension, Subcapsular Cataract, Pancreatic Disturbance, Cushing Like Features, Oedema, Retinal Detachment, Nausea, Vomiting, Insomnia, Nervousness, Nocturia, Increased Appetite, Obesity, Facial Rounding, Fragility Of Skin, Euphoria, Glucose Intolerance.

INTERACTIONS OF DEXAMETHASONE


How Dexamethasone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Dexamethasone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Dexamethasone

No Studies Found