Medicine : Folitrax (20tab)

Name:Folitrax (20tab)
Manufacturer:Ipca Laboratories Ltd
Generic Use:Methotrexate
Composition:Methotrexate(20 Mg)

Generic ( Methotrexate )

Typical use Of Methotrexate :Adjunct In The Short Term Symtomastic Treatment Of Muscle Spasm.
Mechanism of action of Methotrexate :Methotrexate Is A Folic Acid Antagonist That Inhibits DNA Synthesis. It Irreversibly Binds To Dihydrofolate Reductase, Inhibiting The Formation Of Reduced Folates, And Thymidylate Synthetase, Resulting In Inhibition Of Purine And Thymidylic Acid Synthesis.
Drug Interaction of Methotrexate :Decreased Effectiveness With Folic Acid And Its Derivatives. Potentially Fatal: Increased Toxicity With NSAIDs And Salicylates; Probenecid; Some Penicillins; Aminoglycosides Neomycin And Paromomycin; Sulfonamides Such As Sulfafurazole And Sulfamethoxazole; Co-trimoxazole Or Trimethoprim; Nephrotoxic Agents (e.g. Cisplatin); Ciclosporin; Etretinate. Synergistic Enhancement Of Effects With Fluorouracil. Increased Bioavailability Of Mercaptopurine. Reduces Serum-valproate Concentrations. Reduced Serum Concentrations With Colestyramine. Increased Serum Concentrations With Omeprazole.
Side effects of Methotrexate :Ulceration Of The Mouth And GI Disturbances, Bone Marrow Depression, Hepatotoxicity, Renal Failure, Skin Reactions, Alopecia, Megaloblastic Anaemia, Osteoporosis, Precipitation Of Diabetes, Arthralgias, Necrosis Of Soft Tissue And Bone, Anaphylaxis, Impaired Fertility. Potentially Fatal: Pulmonary Reactions (e.g. Interstitial Lung Disease); Neurotoxicity (e.g. Leukoencephalopathy, Paresis, Demyelination) With Intrathecal Use.


How Methotrexate will impact on Pregnancy ?

Information Not Available.

How Methotrexate will impact during lactation(breastfeeding) ?

Information Not Available.

Medicine & Alcohol use and effect of Methotrexate

Information Not Available.