Medicine : Flucort H Skin(15gm)

Name:Flucort H Skin(15gm)
Manufacturer:Glenmark Pharmaceuticals Ltd
Generic Use:Fluocinolone
Composition:Fluocinolone(0.1% W/w)
Substitutes:flucort h skin(15gm) , flucort h skin(20gm)

Generic ( Fluocinolone )

Typical use Of Fluocinolone :Asthma Attacks
Mechanism of action of Fluocinolone :Fluocinonide Binds To The Cytosolic Glucocorticoid Receptor. After Binding The Receptor The Newly Formed Receptor-ligand Complex Translocates Itself Into The Cell Nucleus, Where It Binds To Many Glucocorticoid Response Elements (GRE) In The Promoter Region Of The Target Genes. The DNA Bound Receptor Then Interacts With Basic Transcription Factors, Causing The Increase In Expression Of Specific Target Genes. The Anti-inflammatory Actions Of Corticosteroids Are Thought To Involve Lipocortins, Phospholipase A2 Inhibitory Proteins Which, Through Inhibition Arachidonic Acid, Control The Biosynthesis Of Prostaglandins And Leukotrienes. Specifically Glucocorticoids Induce Lipocortin-1 (annexin-1) Synthesis, Which Then Binds To Cell Membranes Preventing The Phospholipase A2 From Coming Into Contact With Its Substrate Arachidonic Acid. This Leads To Diminished Eicosanoid Production.
Drug Interaction of Fluocinolone :Tell Your Doctor Or Pharmacist Of All Prescription And Nonprescription/herbal Products You May Use, Especially Of Oral Corticosteroids (e.g., Prednisone), Drugs That Suppress The Immune System (e.g., Cyclosporine).
Side effects of Fluocinolone :Telangiectasia, Striae, Glaucoma, Cataract, Growth Retardation, Adrenal Suppression, Epidermal Thinning, Raised Intracranial Pressure, Allergic Reactions, Perioral Dermatitis, Rebound Pustulation.


How Fluocinolone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Fluocinolone will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Fluocinolone

No Studies Found