Medicine : E2 (2)

Name:E2 (2)
Type:Cream
Manufacturer:Sun Pharmaceutical Industries Ltd
Generic Use:Estradiol , Ethanol
Composition:Estradiol(0.06%W/W) , Ethanol(350%W/W)
Substitutes:e2 (2) , e2 (2)


Generic ( Estradiol )


Typical use Of Estradiol :Menopause, Treating Vulval Or Vaginal Atrophy, Prostate Cancer
Mechanism of action of Estradiol :Estradiol Enters Target Cells Freely (e.g., Female Organs, Breasts, Hypothalamus, Pituitary) And Interacts With A Target Cell Receptor. When The Estrogen Receptor Has Bound Its Ligand It Can Enter The Nucleus Of The Target Cell, And Regulate Gene Transcription Which Leads To Formation Of Messenger RNA. The MRNA Interacts With Ribosomes To Produce Specific Proteins That Express The Effect Of Estradiol Upon The Target Cell. Estrogens Increase The Hepatic Synthesis Of Sex Hormone Binding Globulin (SHBG), Thyroid-binding Globulin (TBG), And Other Serum Proteins And Suppress Follicle-stimulating Hormone (FSH) From The Anterior Pituitary.
Drug Interaction of Estradiol :Estradiol. Is Known To Interact With Other Drugs Like Phenytoin (Na), Rifampicin, Sulphamethizole. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Estradiol :Gynacomastia, Uterine Bleeding, Breast Cancer, Endometrial Carcinoma, Headache, Depression, Weight Gain, Nausea And Vomiting, Fluid Retention, Breast Tenderness.

INTERACTIONS OF ESTRADIOL

How Estradiol will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Estradiol will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Estradiol

No Studies Found





Generic ( Ethanol )


Typical use Of Ethanol :Antidote For Methanol Or Ethylene Glycol Ingestion.
Mechanism of action of Ethanol :Ethanol Affects The Brains Neurons In Several Ways. It Alters Their Membranes As Well As Their Ion Channels, Enzymes, And Receptors. Alcohol Also Binds Directly To The Receptors For Acetylcholine, Serotonin, GABA, And The NMDA Receptors For Glutamate. The Sedative Effects Of Ethanol Are Mediated Through Binding To GABA Receptors And Glycine Receptors (alpha 1 And Alpha 2 Subunits). It Also Inhibits NMDA Receptor Functioning. In Its Role As An Anti-infective, Ethanol Acts As An Osmolyte Or Dehydrating Agent That Disrupts The Osmotic Balance Across Cell Membranes.
Drug Interaction of Ethanol :Ethanol Is Known To Interact With Other Drugs Like Abacavir, Gabapentin Enacarbil, Mipomersen, Tizanidine, Triprolidine. Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Ethanol :Emotional Lability, Visual Impairment, Slurred Speech, Ataxia (low To Moderate Concentrations), Hangover Effects Eg, Nausea, Headache, Dizziness, Tremor, Lethargy, Amnesia, Hypothermia, Hypoglycaemia (particularly In Children), Stupor, Coma, Resp Depression, Cardiomyopathy, Hypertension, CV Collapse Damage To Brain And Liver Which May Lead To Wernike-Korsakoff Syndrome (chronic Excessive Alcohol Consumption).

INTERACTIONS OF ETHANOL

How Ethanol will impact on Pregnancy ?

The Drug Should Not Be Used By Pregnant Women. Experiences Of Drug Use And Evidence From Studies In Pregnant Women Have Shown High Risk To Fetus. The Risk Of Drug Use In Pregnant Women Outweighs The Benefit.

How Ethanol will impact during lactation(breastfeeding) ?

Possibly Unsafe: Evidence From Studies In Breastfeeding Women Show That There Is A Definite Risk Of Side Effects To The Breastfed Infants. However, Use Of The Drug In Breastfeeding Women Is Acceptable In Spite Of The Risk To The Infants, If The Drug Is Needed In A Life-threatening Situation Or For A Serious Disease For Which Safer Drugs Cannot Be Used Or Are Ineffective. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Ethanol

No Studies Found