Medicine : Decolp

Name:Decolp
Type:Cream
Manufacturer:Intas Pharmaceuticals Ltd
Generic Use:Chloramphenicol , Dexamethasone , Polymyxin B
Composition:Chloramphenicol(10mg) , Dexamethasone(1Mg) , Polymyxin B(5000Iu)
Substitutes:decolp , decolp , decolp


Generic ( Chloramphenicol )



Typical use Of Chloramphenicol :Enteric Fever (Typhoid And Para Typhoid).H.Influenzae Meningitis. Anaerobic Infections, Intraocular Infections, Urinary Tract Infections, Conjunctivitis, External Ear Infections.Corneal Ulcer, Bacterial Conjunctivitis, Trachoma, Ocular Infections.Otitis Externa, Chronic Otitis Media. Pre And Post Antral Or Mastoid Surgery.
Mechanism of action of Chloramphenicol :Chloramphenicol Is Lipid-soluble, Allowing It To Diffuse Through The Bacterial Cell Membrane. It Then Reversibly Binds To The L16 Protein Of The 50S Subunit Of Bacterial Ribosomes, Where Transfer Of Amino Acids To Growing Peptide Chains Is Prevented (perhaps By Suppression Of Peptidyl Transferase Activity), Thus Inhibiting Peptide Bond Formation And Subsequent Protein Synthesis.
Drug Interaction of Chloramphenicol :Chloramphenicol Is Known To Interact With Other Drugs Like Amoxicillin, Ampicillin, Ascorbic Acid, Azlocillin (Na), Bacampicillin, Benzathine Penicillin, Carbenicillin (Na), Chlorpropamide, Chymotrypsin, Cimetidine (HCl), Ciprofloxacin, Cloxacillin, Clozapine, Colistin (Sulphate & Sulphomethate Na), Cyanocobalamin, Cyclophosphamide, Dicloxacillin (Na), Ethinyloestradiol, Floxacillin (Na), Fosphenytoin, Estodene, Glibornuride, Gliquidone, Hydroxocobalamin, Ichthammol, Iron Dextran, Iron Salts, Iron Sorbitol, Mecillinam, Mecobalamin, Nafcillin, Oxacillin, Paracetamol, Phenobarbitone, Phenytoin (Na), Piperacillin (Na),pivmecillinam (HCl), Primidone, Procaine Penicillin, Promethazine (HCl),rifampicin, Sulfapyridine, Tolbutamide, Warfarin (Na).
Side effects of Chloramphenicol :Encephalopathy, Pseudomembranous Colitis, Anemia, Urticaria, Anemia, Thrombocytopenia, Hepatitis, Ototoxicity, Peripheral Neuropathy, Optic Neuritis, Hemolytic Reactions, Interstitial Nephritis, Headache, Nausea, Vomiting, Maculopapular Rash, Stomatitis, Confusion, Pruritus, Depression, Glossitis, Delirium, Transient Stinging.

INTERACTIONS OF CHLORAMPHENICOL


How Chloramphenicol will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Chloramphenicol will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Chloramphenicol

No Studies Found






Generic ( Dexamethasone )



Typical use Of Dexamethasone :Anorexia In Palliative Care, Congenital Adrenal Hyperplasia, Dyspnoea, Dyspnoea In Palliative Care, Headache Due To Raised Intracranial Pressure In Palliative Care, Nausea And Vomiting (chemotherapy Induced), Pain Due To Nerve Compression In Palliative Care, Raised Intracranial Pressure, Respiratory Distress Syndrome, Shock, Suppression Of Inflammatory And Allergic Disorders.
Mechanism of action of Dexamethasone :Dexamethasone Is A Glucocorticoid Agonist. Unbound Dexamethasone Crosses Cell Membranes And Binds With High Affinity To Specific Cytoplasmic Glucocorticoid Receptors. This Complex Binds To DNA Elements (glucocorticoid Response Elements) Which Results In A Modification Of Transcription And, Hence, Protein Synthesis In Order To Achieve Inhibition Of Leukocyte Infiltration At The Site Of Inflammation, Interference In The Function Of Mediators Of Inflammatory Response, Suppression Of Humoral Immune Responses, And Reduction In Edema Or Scar Tissue. The Antiinflammatory Actions Of Dexamethasone Are Thought To Involve Phospholipase A2 Inhibitory Proteins, Lipocortins, Which Control The Biosynthesis Of Potent Mediators Of Inflammation Such As Prostaglandins And Leukotrienes.
Drug Interaction of Dexamethasone :Tell Your Doctor Of All Prescription And Nonprescription Medication You May Use. Do Not Start Or Stop Any Medicine Without Doctor Or Pharmacist Approval.
Side effects of Dexamethasone :Glaucoma, Peptic Ulceration, Myopathy, Osteoporosis, Growth Retardation, Aseptic Bone Necrosis, Ocular Hypertension, Subcapsular Cataract, Pancreatic Disturbance, Cushing Like Features, Oedema, Retinal Detachment, Nausea, Vomiting, Insomnia, Nervousness, Nocturia, Increased Appetite, Obesity, Facial Rounding, Fragility Of Skin, Euphoria, Glucose Intolerance.

INTERACTIONS OF DEXAMETHASONE


How Dexamethasone will impact on Pregnancy ?

Studies In Animals Have Shown Risk To Fetus, However There Are No Sufficient Studies In Humans. This Drug May Be Used In Pregnant Women If Benefit Outweighs The Risk. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Dexamethasone will impact during lactation(breastfeeding) ?

Contraindicated: The Drug Should Not Be Used By Breastfeeding Women, As Evidences From Studies Have Shown That There Is A High Risk Of Causing Significant Damage To Infants.

Medicine & Alcohol use and effect of Dexamethasone

No Studies Found






Generic ( Polymyxin B )



Typical use Of Polymyxin B :Bacterial Conjunctivitis, And Blepharoconjunctivitis
Mechanism of action of Polymyxin B :Polymyxin B Interacts With The Lipopolysaccharide Of The Cytoplasmic Outer Membrane Of Gram-negative Bacteria, Altering Membrane Permeability And Causing Cell Death.
Drug Interaction of Polymyxin B :Polymyxin B (Sulphate) Is Known To Interact With Other Drugs Like Alcuronium (Cl), Amphotericin B, Atracurium (Besylate), Botulinum Toxin Type A, Capreomycin, Cephalothin (Na), Distigmine (Br), Floxacillin (Na), Neostigmine, Tobramycin, Vecuronium (Br). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.
Side effects of Polymyxin B :Convulsions, Coma, Psychosis, Hypersensitivity Reactions, Neuromuscular Blockage, Nephrotoxicity, Neurotoxicity, Hematuria, Dizziness, Drowsiness, Ataxia, Nausea, Vomiting, Blurred Vision, Confusion, Urticaria, Flushing, Muscle Weakness, Paresthesias, Proteinuria.

INTERACTIONS OF POLYMYXIN B


How Polymyxin B will impact on Pregnancy ?

Studies In Animals Have Shown No Risk To The Fetus, However There Are No Sufficient Studies In Humans. Patients Should Follow The Advice Of The Doctor Regarding Its Use. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

How Polymyxin B will impact during lactation(breastfeeding) ?

Moderately Safe: No Studies Have Been Conducted In Breastfeeding Women, However There Is Possibility Of Ill Effect To The Breastfed Infants; Or Studies Conducted In Breastfeeding Women Show Minimal Non-threatening Side Effects To The Infants. Drugs Should Be Given Only If The Potential Benefit Justifies The Potential Risk To The Infant. Patients Should Follow The Advice Of The Doctor Regarding Its Use.

Medicine & Alcohol use and effect of Polymyxin B

No Studies Found